Th1 / Th2平衡:假设,它的局限性,对健康和疾病的影响。

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Th1 / Th2平衡:假设,它的局限性,对健康和疾病的影响。

交错的地中海启2003;8月8 (3):223 - 46。

PubMed ID

12946237 (在PubMed

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文摘

一个理论之间的免疫调控涉及体内平衡辅助1 (Th1)和辅助2 (Th2)活动。Th1 / Th2假说源于1986年的一项调查显示鼠标辅助细胞表达细胞因子不同模式。这个假设是适应人体免疫力,Th1和Th2-helper细胞指挥不同的免疫反应通路。Th1细胞驱动1型通路(细胞免疫)对抗病毒和其他细胞内病原体,消除癌细胞,并刺激DTH皮肤反应(DTH)。Th2细胞驱动(体液免疫)和2型通路调控的抗体生产抗细胞外生物;2型优势被认为对异种移植的宽容和怀孕期间胎儿的。Overactivation模式可以引起疾病,和其他途径可以抑制。但假设主要矛盾;人类细胞因子活动很少落入独家pro-Th1或th2模式。non-helper调节性T细胞、抗原呈递细胞(APC),可能影响免疫的方式与Th1、Th2细胞。 Many diseases previously classified as Th1 or Th2 dominant fail to meet the set criteria. Experimentally, Th1 polarization is readily transformed to Th2 dominance through depletion of intracellular glutathione, and vice versa. Mercury depletes glutathione and polarizes toward Th2 dominance. Several nutrients and hormones measurably influence Th1/Th2 balance, including plant sterols/sterolins, melatonin, probiotics, progesterone, and the minerals selenium and zinc. The long-chain omega-3 fatty acids EPA (eicosapentaenoic acid) and DHA (docosahexaenoic acid) significantly benefit diverse inflammatory and autoimmune conditions without any specific Th1/Th2 effect. Th1/Th2-based immunotherapies, e.g., T-cell receptor (TCR) peptides and interleukin-4 (IL-4) injections, have produced mixed results to date.

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