(四环素和glycylcyclines的药物)。

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Vojtova V,他K

(四环素和glycylcyclines的药物)。

Klin Mikrobiol Infekc列克。2009年2月;。17 - 21(1):15个区间

PubMed ID

19399726 (在PubMed

]

文摘

Glycylcyclines来自四环素的化学结构。之后他们开始用于临床实践,四环素组来到焦点作为一个整体。第一代四环素特性lipophilia低,他们通常只口周围的形式,除了罗利环素。此外,他们的吸收是非常变量和不完整的,通常从25%到60%不等(四环素的吸收范围从77%到88%)。大多数第一代四环素不代谢(尽管5%的四环素是代谢活性代谢物)。相反,他们通常被肾排泄。第二代四环素是亲脂性的3到5倍,这增强了他们的组织渗透。强力霉素,这群最常见的功能生物利用度80%以上。胆汁的强力霉素浓度高出10到25倍相比,其血清浓度。高浓度的强力霉素被发现在肾脏、肝脏和肠道。 Primarily, doxycycline is excreted in bile to feces. Part of doxycycline is inactivated in the liver and 40 % of it is excreted by kidneys in urine. Tigecycline is administered intravenously and it shows high tissue penetration, especially in bones, skin, liver and lungs. Less than 20 % of tigecycline is metabolized before it is excreted. Primarily, it is eliminated by biliary/fecal excretion in unchanged form. Small part of tigecycline is eliminated as metabolites. Secondary routes of elimination are glucuronidation and renal excretion.

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药物

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