22,mrp2-mediated octreotide运输在肾近端小管。

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古特曼H,米勒DS, Droulle Drewe J, Fahr,弗里克G

22,mrp2-mediated octreotide运输在肾近端小管。

Br J杂志。2000年1月,129 (2):251 - 6。doi: 10.1038 / sj.bjp.0703003。

PubMed ID

10694230 (在PubMed

]

文摘

1。Transepithelial运输荧光的导数octreotide (NBD-octreotide)研究了在新孤立的,功能完整的肾近端小管那从鳉鱼(Fundulus heteroclitus)。2。药物积累在管腔可视化通过共焦显微镜和图像分析测量。NBD-octreotide分泌到管腔了,表现出特定和依赖资源运输的所有特征。稳态腔的荧光平均5次细胞荧光和减少代谢被NaCN抑制时细胞水平。beplayapp3所示。NBD-octreotide分泌抑制浓度的方式是未标记的octreotide,维拉帕米和白三烯C (4) (LTC (4))。相反,未标记的octreotide减少以浓度依赖方式22 (Pgp)介导的荧光环孢菌素的分泌导数(NBDL-CS)和mrp2-mediated荧光素的分泌甲氨蝶呤(FL-MTX)。4所示。 This inhibition was not due to impaired metabolism or toxicity since octreotide had no influence on the active transport of fluorescein (FL), a substrate for the classical renal organic anion transport system. 5. The data are consistent with octreotide being transported across the brush border membrane of proximal kidney tubules by both Pgp and mrp2.

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药物转运蛋白

药物	转运体	类	生物	药理作用	行动
Octreotide	微管的multispecific有机阴离子转运体1	蛋白质	人类	未知的	底物 抑制剂	细节
Octreotide	22 - 1	蛋白质	人类	未知的	底物	细节