有一个角色(99米)Tc-anti-CEA单克隆抗体成像在结直肠癌复发的诊断?

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柱身D, Maurel J,木西,Setoain X, Ayuso C,马丁F,奥尔特加ML,要塞,脑桥F

有一个角色(99米)Tc-anti-CEA单克隆抗体成像在结直肠癌复发的诊断?

问J诊断。2003年6月,47(2):109 - 15所示。

PubMed ID

12865871 (在PubMed

]

文摘

目的:评估的有效性immunoscintigraphy一个anti-CEA单克隆抗体片段贴上了Tc(99米)的早期检测大肠癌复发患者的血清CEA水平上升。方法:连续51例(27名女性,24岁男性)与结直肠癌(平均年龄68.9 + / - -10.2年)和CEA水平上升(16.2 + / - -18.2 ng / ml)前瞻性研究。两个immunoscintigraphy研究进行8例(n = 59)。Immunoscintigraphy进行静脉输液注射后925兆贝可anti-CEA单克隆抗体。平面图像的胸、腹部和骨盆,SPECT的腹部和骨盆得到4,注射后24小时。在所有情况下腹部CT扫描之前执行。通过组织病理学分析结果验证(28例)或通过影像学和临床随访至少6个月后immunoscintigraphy(31例)。结果:41例随访期间没有复发。我们发现18例确诊的诊断肝外腹部或盆腔疾病,11例肝转移,9在胸腔和2骨头。骨盆和腹部肝外疾病患者,immunoscintigraphy积极在18例(14真阳性,4假阳性)。 From the 14 true positive only 7 cases had been detected by CT. Immunoscintigraphy was negative in the remaining 41 cases (37 true negative, 4 false negative). Therefore, the sensitivity and specificity for immunoscintigraphy in extrahepatic abdominal and pelvic disease were 78% and 90%, respectively. CT results showed a lower sensitivity of 61% (p<0.05) and specificity of 83%. Liver metastases were detected by CT in 9 cases, but only 2 of these were identified using immunoscintigraphy. CONCLUSION: Scintigraphy with anti-CEA monoclonal antibody fragment labelled with (99m)Tc is superior to CT for the detection of pelvic and extrahepatic abdominal recurrence of colorectal cancer, while CT is more sensitive in the detection of liver and lung metastases. Immunoscintigraphy has a limited usefulness in the detection of distant metastases, but it may be helpful in the diagnosis of suspected colorectal recurrence in patients with non-conclusive CT findings, when FDG-PET is not available.

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药物靶点

药物	目标	类	生物	药理作用	行动
锝tc - 99 m arcitumomab	癌胚antigen-related细胞粘附分子1	蛋白质	人类	未知的	其他/未知	细节