功效的3 c蛋白酶抑制剂在治疗各种形式的获得猫传染性腹膜炎。
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皮德森数控,金正日Y,刘H, Galasiti Kankanamalage AC, Eckstrand C, Groutas WC, Bannasch M,草地JM, Chang KO
功效的3 c蛋白酶抑制剂在治疗各种形式的获得猫传染性腹膜炎。
J猫Surg. 2018年4月,20 (4):378 - 392。doi: 10.1177 / 1098612 x17729626。Epub 2017年9月13日。
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28901812 (在PubMed]
- 文摘
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目标的安全性和有效性3 c蛋白酶抑制剂GC376测试与各种形式的群client-owned猫猫传染性腹膜炎(金)。方法20只猫从-82年的3.3个月(平均10.4个月)与各种形式的工厂检验计划被接受为现场试验。14个猫了湿或dry-to-wet工厂检验计划和六只猫出现干燥的工厂检验计划。GC376皮下注射的剂量每12 h 15毫克/公斤。猫与神经信号被排除在研究之外。结果19 20猫治疗两周内与外GC376恢复健康的初始治疗。然而,疾病复发迹象1 - 7周后主要治疗和复发和新病例最终治疗至少12周。治疗复发不再响应发生在13日的19日猫1 - 7周内的初始或重复治疗。严重的神经系统疾病发生在8/13猫失败的治疗和五猫腹部病变复发。在撰写本文时,七只猫在疾病缓解。 Five kittens aged 3.3-4.4 months with wet FIP were treated for 12 weeks and have been in disease remission after stopping treatment and at the time of writing for 5-14 months (mean 11.2 months). A sixth kitten was in remission for 10 weeks after 12 weeks of treatment, relapsed and is responding to a second round of GC376. The seventh was a 6.8-year-old cat with only mesenteric lymph node involvement that went into remission after three relapses that required progressively longer repeat treatments over a 10 month period. Side effects of treatment included transient stinging upon injection and occasional foci of subcutaneous fibrosis and hair loss. There was retarded development and abnormal eruption of permanent teeth in cats treated before 16-18 weeks of age. Conclusions and relevance GC376 showed promise in treating cats with certain presentations of FIP and has opened the door to targeted antiviral drug therapy.
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