甲氟喹合成,回顾其抗疟活性,药代动力学性质和治疗效果。

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帕默KJ,霍利迪SM, Brogden RN

甲氟喹合成,回顾其抗疟活性,药代动力学性质和治疗效果。

药。1993年3月,45 (3):430 - 75。doi: 10.2165 / 00003495-199345030-00009。

PubMed ID

7682911 (在PubMed

]

文摘

甲氟喹合成是一种口头管理schizontocide血。初步研究和比较研究在1977年和1989年之间执行演示效果在多发地个人和甲氟喹合成,预防疟疾的抑制和治疗耐多药恶性疟原虫引起的成人和儿童。对间日疟原虫感染也有效,而数据有关p .那和三日疟原虫感染的治疗是有限的。为了推迟耐药性的出现对这个有前途的抗疟代理,mefloquine结合磺胺多辛和息疟定。虽然最初的临床试验表明,该方案是有效的预防和治疗恶性疟疾,最近的治疗失败,潜在的严重皮肤反应和缺乏治疗优势mefloquine独自促使世界卫生组织建议结合不再用于治疗或预防疟疾。Mefloquine在成人和儿童一般耐受性良好,有恶心、呕吐、腹泻、头痛、头晕、皮疹,瘙痒和腹痛最常见的不良反应,尽管很难区分疾病和治疗相关的事件。这些不良反应的发生率类似于或低于观察与其它抗疟药物。心血管变化,如心动过缓,偶尔发生。最显著的不利影响与mefloquine相关神经精神障碍;降水的此类事件应密切监测,需要终止的预防或治疗。 The eventual emergence of resistance to mefloquine, as with many other antimalarial agents, was inevitable. Mefloquine resistance is established in certain areas of Thailand and may be becoming a growing problem in other regions of the world. In order to preserve the efficacy of mefloquine in non-resistant areas, this useful agent should be used with care and only prescribed for prophylaxis in travellers and treatment in areas of multidrug-resistant plasmodia. Future options to combat mefloquine resistance may include the combination of mefloquine with other antimalarial agents such as qinghaosu derivatives. Thus, with cautious use and possible combination with other agents, mefloquine is likely to remain an important treatment option for falciparum malaria, a widespread parasitic disease for which an increasing number of drugs have proved inadequate.

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药物

甲氟喹