泊沙康唑:口服苯三唑和扩展的频谱活动。

文章的细节

引用

复制到剪贴板

Rachwalski EJ、Wieczorkiewicz JT Scheetz MH

泊沙康唑:口服苯三唑和扩展的频谱活动。

安Pharmacother。2008年10月,42 (10):1429 - 38。doi: 10.1345 / aph.1L005。Epub 2008年8月19日。

PubMed ID

18713852 (在PubMed

]

文摘

摘要目的:总结发表在泊沙康唑临床数据,批判性审查新药应用程序数据提交给美国食品和药物管理局,并提供评价和规定的定位的关键信息。数据来源:调查报告被确认来自MEDLINE(1966 - 2008年6月30日),参考书目的手稿,www.clinicaltrials.gov, www.fda.gov。研究选择和数据提取:英文文章被选中。所有可用体外、动物、临床和人类研究描述药理学、药物动力学、药效学,泊沙康唑的疗效、安全性和不良事件。数据综合:泊沙康唑口服广谱三唑与活动对许多酵母菌和霉菌。抵制泊沙康唑被报道,但已经罕见。泊沙康唑,每日3次、每次200毫克的剂量,减少突破侵袭性真菌感染(或0.30;95%可信区间0.12到0.71)和曲霉病发病率(或0.31;95%可信区间0.13到0.75)在接受造血干细胞移植的病人相比,那些接受氟康唑。同样,相同方案的泊沙康唑降低侵袭性真菌感染(95% CI -9.7 - -2.5)和曲霉病(CI没有报告,p < 0.001)与氟康唑和伊曲康唑相比粒细胞减少性病人。 Posaconazole is noninferior to fluconazole for treatment of oropharyngeal candidiasis (95% CI -6.6 to 5.0), but necessity for this indication remains unclear, as many other treatment options exist. Smaller investigations have analyzed use of posaconazole for patients requiring salvage or alternative treatment for zygomycosis, fusariosis, cryptococcal meningitis, coccidioidomycosis, and histoplasmosis. Studies are needed to clarify efficacy for such expanded use, and therapeutic drug monitoring may improve outcomes. The most common adverse effects associated with the use of posaconazole include headache, fever, nausea, vomiting, and diarrhea. CONCLUSIONS: Posaconazole appears to be a valuable and promising addition to the antifungal armamentarium for prophylaxis and treatment of various fungal processes. At this time, posaconazole should probably be reserved for prophylaxis in patients at high risk for invasive fungal infection, as salvage therapy in refractory or resistant infections, or for patients with intolerance to other therapies.

beplay体育安全吗DrugBank数据引用了这篇文章

药物

泊沙康唑