磷霉素:使用除了尿路和胃肠道感染。

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Falagas我,Giannopoulou KP, Kokolakis GN, Rafailidisπ

磷霉素:使用除了尿路和胃肠道感染。

中国感染说。2008年4月1;46 (7):1069 - 77。doi: 10.1086/527442。

PubMed ID

18444827 (在PubMed

]

文摘

新抗菌药物的短缺使得科学界考虑老抗生素的潜在价值。搜索的文献进行编译相关证据关于磷霉素治疗的有效性和安全性的革兰氏阳性和/或革兰氏阴性细菌感染患者(排除尿路感染和胃肠道感染)。1311潜在的相关研究,详细综述了62项研究。1604年各种革兰氏阳性和革兰氏阴性患者感染各种身体的网站(包括肺炎和其他呼吸道感染;骨髓炎;脑膜炎;耳、鼻、喉感染;外科感染;产科和妇科感染;关节炎; septicemia; peritonitis; cervical lymphadenitis; eye infections; diabetic foot infections; and typhoid fever) being treated with fosfomycin alone or in combination with other antibiotics, cure was achieved in 1302 (81.1%) of the patients, and improvement was noted in 47 (2.9%). In comparative perioperative prophylaxis trials that included a total of 1212 patients (mainly patients undergoing colorectal surgery), the fosfomycin-metronidazole combination led to results that were similar to those achieved with the combination of other antibiotics (doxycycline, ampicillin, or cephalothin) and metronidazole. In an era in which there is a shortage of new antibiotics, fosfomycin might be considered to be an alternative treatment agent for infections caused by gram-positive and gram-negative bacteria, in addition to its traditional use in treating uncomplicated urinary tract and gastrointestinal infections. Further research on the in vitro antimicrobial activity of fosfomycin, especially against multidrug-resistant pathogens (such as extended-spectrum beta-lactamase-producing and/or metallo-beta-lactamase-producing enterobacteriaceae and Pseudomonas aeruginosa, and on the effectiveness and safety of the drug in the treatment of patients with such infections may be warranted.

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药物

磷霉素