通用汽车- 006符合FDA建议用药与卡铂beplayapp

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迪亚兹厘米,Fenix-Caballero科幻,Palomo-Palomo C, Gandara-Ladronde Guevera MJ, Alegre-DelRey EJ, Blanco-Castano MA Lopez-Vallejo摩根富林明,Diaz-Navarro J, Borrero-Rubio JM, Rios-Sanchez E

通用汽车- 006符合FDA建议用药与卡铂beplayapp

欧洲医院药学杂志:科学和实践。2014年2月24日,21 (1):A116。

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背景在2010年底,美国食品和药物管理局发布警报有关使用血清肌酐测定的新方法。IDMS方法似乎低估了血清肌酐值比旧方法当血清肌酐值相对较低(例如,~ 0.7 mg / dL)。这可能会导致更高的剂量比必要和卡铂的毒性。因此建议使用固定的最大剂量为每个目标AUC值。目的确定符合美国食品药品管理局对卡铂剂量的建议,并评估出现的毒性高于推荐剂量。beplayapp材料和方法的总体数量患者和卡铂课程,性别、年龄、诊断和过量百分比从Farmis数据库提取抑制细胞生长的管理,从2011年1月到2013年9月。过量指定:卡铂剂量> 900毫克为目标AUC = 6;卡铂剂量> 750毫克为目标AUC = 5;卡铂剂量>目标AUC = 4 600毫克。如果用药(常见的术语标准不良事件(CTCAE)标准),血液测试之前寻求下一轮的治疗和需要延迟化疗治疗进行评估。 Results A total of 195 patients and 763 courses of carboplatin were identified; 18 patients (2%) had been given an excessive dose. Toxicity was caused in 3 women and 4 men by overdosing with carboplatin, with an average of 48 years and different cancers: lung (N = 2), stomach (N = 1), ovary (N = 2) and unknown origin (N = 2). Following evaluation of the eighteen patients who had received an excessive dose, 22.2% of their chemotherapy courses were delayed. Conclusions As so many patients are exposed to toxicity in this way, it is necessary to set up an automated alert system based on FDA recommendations. Neutropenia was the only adverse event for which chemotherapy had to be postponed; there was no thrombocytopenia.

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