血管舒张药硝酸异山梨酯对眼部血液循环的影响。

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Hessemer V,施密特公斤

血管舒张药硝酸异山梨酯对眼部血液循环的影响。

角膜切削。1997年3月,115 (3):324 - 7。doi: 10.1001 / archopht.1997.01100150326003。

PubMed ID

9076203 (在PubMed

]

文摘

目的:评价血管舒张药硝酸异山梨酯眼部血流动力学的影响。设计:随机、前瞻性对照临床试验评估1平板的短期效应包含40毫克的硝酸异山梨酯和安慰剂。设置:德国吉森大学眼科学系。主要结果测量:眼动脉压(SOAP),收缩压眼部灌注压(SOPP),眼脉动振幅(OPA), OPA x心率(HR)的产物,眼内压(IOP),收缩压和舒张压(SBAP和DBAP)肱动脉压力。测量之前进行,7小时后患者接受药物治疗。参与者:20个健康受试者(平均年龄28岁)提供知情同意。结果:硝酸异山梨酯后管理,SBAP,肥皂,和SOPP明显降低(P = . 01),而眼压倾向于更低(P =。08)与安慰剂相比。最大限度的减少3 - 5小时后药物:SBAP降低了10.9毫米汞柱(减少9%;P = . 01),香皂是减少12.5毫米汞柱(减少14%;P = . 01), SOPP降低了11.3毫米汞柱(减少14.5%; P = .01), and IOP by 1.5 mm Hg (12% reduction; P = .08). The relation between SBAP and SOAP was significantly linear (P < .001), the correlation coefficient was 0.39. The DBAP remained unchanged, and the HR increased by 4 to 7/min (P = .08). The OPA and the product OPA x HR were significantly decreased (P < .001; P = .002) by maximum values of 44% and 40%, respectively. CONCLUSIONS: Administration of isosorbide dinitrate reduced SOAP and SOPP, reflecting reduced systemic systolic blood pressure. The decrease in OPA and the product OPA x HR (a measure of pulsatile ocular blood flow) may reflect a reduction in cardiac stroke volume typical for nitrates. Due to these hemodynamic effects and the minute reduction in IOP, the vasodilator drug isosorbide dinitrate, which has been proposed for glaucoma therapy, may be used only with caution in patients with glaucoma.

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药物

异山梨醇