荟萃分析:高剂量维生素E补充剂可能增加死亡率。
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米勒ER 3日Pastor-Barriuso R, Dalal D, Riemersma RA, Appel LJ, Guallar E
荟萃分析:高剂量维生素E补充剂可能增加死亡率。
安实习生地中海。2005年1月4日,142 (1):37-46。Epub 2004 11月10。
- PubMed ID
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15537682 (在PubMed]
- 文摘
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背景:实验模型和观测研究表明,补充维生素E可以预防心血管疾病和癌症。然而,一些高剂量维生素E补充剂的试验显示非统计性在总死亡率显著增加。目的:执行一个荟萃分析的补充维生素E和总死亡率之间的剂量-反应关系通过使用数据从随机,对照试验。病人:135967名参与者在19个临床试验。这些试验,仅9测试维生素E维生素E和10个测试结合其他维生素或矿物质。维生素E的剂量范围从16.5到2000 IU / d(中位数,400 IU / d)。数据来源:PubMed搜索从1966年到2004年8月,辅以Cochrane临床试验数据库的搜索和审查的引用发表评论和荟萃分析。没有语言的限制。数据提取:3独立调查人员抽象研究报告。调查人员最初的出版物是联系如果需要信息是不可用的。 DATA SYNTHESIS: 9 of 11 trials testing high-dosage vitamin E (> or =400 IU/d) showed increased risk (risk difference > 0) for all-cause mortality in comparisons of vitamin E versus control. The pooled all-cause mortality risk difference in high-dosage vitamin E trials was 39 per 10,000 persons (95% CI, 3 to 74 per 10,000 persons; P = 0.035). For low-dosage vitamin E trials, the risk difference was -16 per 10,000 persons (CI, -41 to 10 per 10,000 persons; P > 0.2). A dose-response analysis showed a statistically significant relationship between vitamin E dosage and all-cause mortality, with increased risk of dosages greater than 150 IU/d. LIMITATIONS: High-dosage (> or =400 IU/d) trials were often small and were performed in patients with chronic diseases. The generalizability of the findings to healthy adults is uncertain. Precise estimation of the threshold at which risk increases is difficult. CONCLUSION: High-dosage (> or =400 IU/d) vitamin E supplements may increase all-cause mortality and should be avoided.
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