相关药物对心脏功能的影响,大型动脉,阻力血管。
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Fabry搞笑,德Paepe P,逃学詹,范Bortel LM
相关药物对心脏功能的影响,大型动脉,阻力血管。
欧元中国新药杂志。2011年6月,67 (6):573 - 80。doi: 10.1007 / s00228 - 011 - 1040 - 5。Epub 2011年4月15日。
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21494767 (在PubMed]
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目的:β2肾上腺素能受体论争的药品如羟苄羟麻黄碱参考相关药物,但与心血管副作用。Atosiban,一种新型毒品,是一个竞争对手的催产素和一直宣称心血管副作用更少。直到现在,主要有主观报告的不良反应和一些客观的心血管数据。评估治疗的急性效应剂量的羟苄羟麻黄碱和atosiban心脏功能与安慰剂比较,大型动脉属性,血压,和阻力血管。方法:双盲随机试验进行了20没有怀孕女性志愿者。期间血流动力学测量是在标准条件下动力学稳定状态。用超声心动图测定心输出量、大型动脉与echo-tracking设备属性。对微循环的影响估计使用总外周阻力指数(TPRI)。结果:Atosiban没有不同于安慰剂。羟苄羟麻黄碱,心脏功能增加了79%与安慰剂比较,因为心率上升(91%)。 TPRI decreased by 48%. Ritodrine increased the distensibility of the common carotid artery by 62% and the compliance by 83%, independent of blood pressure. Compliance of the common femoral artery increased independently of pressure by 33% and the distensibility by 59%. Aortic pulse wave velocity was not influenced by either medication. CONCLUSIONS: The present study shows potential beneficial vascular effects of ritodrine that are counterbalanced by the cardiac effects. Atosiban has no clinically relevant cardiovascular effects and may be a good alternative for ritodrine in pregnant women at risk of cardiovascular complications.