oxybate钠对生长激素分泌的影响在嗜睡症患者和健康对照组。
文章的细节
-
引用
复制到剪贴板 -
Donjacour CE,阿齐兹NA, Roelfsema F, Frolich M, Overeem年代,拉默斯GJ,特H
oxybate钠对生长激素分泌的影响在嗜睡症患者和健康对照组。
是杂志性金属底座。2011年6月,300 (6):e1069 - 75。doi: 10.1152 / ajpendo.00623.2010。Epub 2011年3月29日。
- PubMed ID
-
21447786 (在PubMed]
- 文摘
-
食欲素缺乏引起嗜睡症和可能影响神经内分泌系统和身体成分。此外,生长激素(GH)改变我影响重量的嗜睡症。可以有效治疗症状钠oxybate (SXB;γ)的许多病人。本研究相比,生长激素分泌的病人和匹配控制的影响,建立了SXB政府在两组GH和睡眠。八公hypocretin-deficient嗜睡症患者和猝倒和八个控制匹配性、年龄、体重指数、腰臀比、脂肪比例录取。血液采样前后的第五天SXB管理。SXB拍摄两次3 g /晚上连续5天。每隔10分钟两组接受24小时的血液抽样GH浓度的测量。分析了GH浓度时间序列AutoDecon和近似熵(ApEn)。 Basal and pulsatile GH secretion, pulse regularity, and frequency, as well as ApEn values, were similar in patients and controls. Administration of SXB caused a significant increase in total 24-h GH secretion rate in narcolepsy patients, but not in controls. After SXB, slow-wave sleep (SWS) and, importantly, the cross-correlation between GH levels and SWS more than doubled in both groups. In conclusion, SXB leads to a consistent increase in nocturnal GH secretion and strengthens the temporal relation between GH secretion and SWS. These data suggest that SXB may alter somatotropic tone in addition to its consolidating effect on nighttime sleep in narcolepsy. This could explain the suggested nonsleep effects of SXB, including body weight reduction.
beplay体育安全吗DrugBank数据引用了这篇文章
- 药物