Dipyrone过量。
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科恩林杰宏Y, O
Dipyrone过量。
42 J Toxicol Toxicol。2004; (3): 261 - 5。doi: 10.1081 /活体供体- 120037425。
- PubMed ID
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15362592 (在PubMed]
- 文摘
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背景:Dipyrone是吡唑啉酮衍生物用作止痛和退热的。粒细胞缺乏症,dipyrone最严重,可能致命的负面影响,导致其在若干国家撤军。然而,粒细胞缺乏症是受制于地理变异,比在风险从0.8到-23.7不等。在许多国家dipyrone仍广泛应用于成人和儿童,甚至作为一个场外交易(OTC)准备。信息dipyrone过量的影响极为有限。目的:确定dipyrone过量的人口和临床特点。方法:回顾性研究的前瞻性收集急性中毒中心数据接触dipyrone在三年内。数据进行描述性分析。Mann-Whitney和卡方分析进行相关测试。结果:共有243条记录符合纳入和排除标准。 Median age was 17y (4m-83y), median amount 5 g (250 mg-45 g), and median time to consultation was 2 h (5 min-48 h). Toxic events (49) occurred in 39 (16%) patients; 57% of these were gastrointestinal and all were mild. Time to consultation was longer in the symptomatic patients (4 h vs. 1.5 h, respectively, p=0.001) and in children (8 h vs. 3.5 h in adults). Suicidal patients ingested significantly larger amounts (8 g vs. 3.7 g, respectively, p=0.001), as did patients with gastrointestinal symptomatology (7.5 g vs. 5 g in asymptomatics, p=0.001). No agranulocytosis was reported. DISCUSSION: Dipyrone overdose is associated with mild, mainly gastrointestinal toxicity; this was noted at a median dose of 7.5 g. Early gastrointestinal decontamination may have prevented toxicity. The suggested treatment includes gastrointestinal decontamination (if <1 h since ingestion) and supportive measures.
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