metamizole的药理特性。

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Jasiecka,马兰斯卡T, Jaroszewski JJ

metamizole的药理特性。

波尔J兽医科学。2014;17(1):207 - 14所示。doi: 10.2478 / pjvs - 2014 - 0030。

PubMed ID

24724493 (在PubMed

]

文摘

Metamizole (dipyrone)是一个受欢迎的止痛剂,为靶标的药物,常用于人类和兽医。在某些情况下,这个代理还不正确归类为非甾体抗炎药(非甾体抗炎药)。Metamizole是一个前药,口服后自发分解结构相关的吡唑啉酮化合物。除了其镇痛效果,药物治疗是一个退热剂,解痉的代理。负责止痛效应的机制是一个复杂的一个,也是最可能取决于中央cyclooxygenase-3和激活的抑制opioidergic系统和大麻素系统。Metamizole可以阻止PG-dependent和PG-independent通路LPS引起的发烧,这表明这种药物退热的作用截然不同的配置文件,非甾体抗炎药。负责metamizole的解痉药效果的机制与细胞内钙离子的释放抑制磷酸肌醇的合成的结果。Metamizole主要是应用于治疗不同病因的疼痛,痉挛的条件,特别是影响消化道,和其他治疗发烧耐火材料。合并施打吗啡和metamizole产生超加性,antinociceptive效果。Metamizole是相对安全的药物制剂虽然并非完全无不良影响。 Among these side-effects, the most serious one that raises most controversy is the myelotoxic effect. It seems that in the past the risk of metamizole-induced agranulocytosis was exaggerated. Despite the evidence showing no risk of teratogenic and embryotoxic effects, the drug must not be administered to pregnant women, although it is allowed to be given to pregnant and lactating animals. This paper seeks to describe the characteristics of metamizole in the light of current knowledge.

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药物

Metamizole