Imipenem-cilastatin钠、广谱碳青霉烯抗生素组合。

文章的细节

引用

复制到剪贴板

柔和的哒

Imipenem-cilastatin钠、广谱碳青霉烯抗生素组合。

中国制药。1986年9月,5 (9):719 - 36。

PubMed ID

3530614 (在PubMed

]

文摘

化学、抗菌谱、作用机制、药理学和药物动力学,临床应用,不良反应,剂量和管理,在治疗,成本效益,规定考虑imipenem-cilastatin钠进行了综述。Imipenem thienamycin类的是第一个碳青霉烯抗生素临床使用。Imipenem具有宽的光谱抗菌活性的当前可用beta-lactam代理,其他beta-lactam抗生素相比,缺乏交叉耐药性最近推出了extended-spectrum青霉素和第三代头孢菌素。对革兰氏阳性和革兰氏阴性需氧和厌氧生物,imipenem展示优秀的活动。假单胞菌maltophilia,一些假单胞菌菌株不过并抗链球菌都有效。耐甲氧西林葡萄球菌菌株也应该被视为抵抗imipenem。为临床使用imipenem coadministered与cilastatin相等的部分。Cilastatin肾dehydropeptidase抑制剂,抑制由肾imipenem小肠的代谢酶,从而增加imipenem尿液的浓度。Imipenem-cilastatin仅由静脉的路线。imipenem-cilastatin类似于t的不良反应资料其他beta-lactam抗生素。 Recommended dosage reductions appropriate for renal impairment should be guided by periodic assessments of renal function, with close adherence to recommended dosage schedules, particularly among patients who are predisposed to seizures or receiving anticonvulsant medication. Imipenem-cilastatin performed well in both comparative and noncomparative trials of clinical efficacy and safety. For infections with multiple organisms (e.g., pelvic, intra-abdominal, or soft-tissue infections), imipenem-cilastatin may be a cost-effective and less toxic single-agent alternative to "standard" combination (e.g., aminoglycoside-penicillin plus an antianaerobic agent) therapy. However, in patients with serious pseudomonal infections (e.g., pneumonia), isolates may rapidly acquire resistance to imipenem or be replaced by resistant strains of Ps. aeruginosa when imipenem is used alone. Therefore, when the recovery of Ps. aeruginosa is anticipated or documented, treatment with imipenem-cilastatin should include an aminoglycoside to reduce the likelihood of the emergency of resistant organisms during therapy.

beplay体育安全吗DrugBank数据引用了这篇文章

药物

Imipenem