非盲、剂量升级试点研究的影响氯硝西泮灼口综合征。

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Grushka M,爱泼斯坦J,莫特

非盲、剂量升级试点研究的影响氯硝西泮灼口综合征。

口腔杂志口腔医学口腔病理学研究口腔Radiol Endod。1998年11月,86 (5):557 - 61。doi: 10.1016 / s1079 - 2104 (98) 90345 - 6。

PubMed ID

9830647 (在PubMed

]

文摘

目的:目前治疗灼口综合征通常是针对修正检测有机原因或者是经验主义的,它通常包括三环类抗抑郁药物的使用。最近,有兴趣重燃灼口综合征的使用苯二氮卓类。本研究旨在评估氯硝西泮在灼口综合征的效果。研究设计:30例,每个主诉的嘴燃烧没有口腔粘膜病变,进入了研究。所有患者接受常规血液屏幕。确定异常纠正,如果可能,在氯硝西泮规定。起始剂量为0.25毫克每日,每周0.25毫克剂量的增加,如果症状持续。结果:人口由29名女性和1人。所有受试者被症状(平均发病前的燃烧强度,7.0 + / - 1.9在10分制)1月12年(意思是,3.9 + / - 3.4年;值,2.75年),16%有燃烧超过2年。 Three groups of patients were identified: those who experienced partial to complete relief with clonazepam and who were using the medication at the last follow-up (group 1; 43%); those who found the clonazepam helpful but withdrew from the medication because of side effects--usually drowsiness (group 2; 27%); and those who did not benefit from clonazepam (group 3; 30%). Among the 3 groups, age was found to be significantly lower for group 1 than for group 2 but not significantly lower for group 1 than for group 3. Although the difference did not reach significance, the mean dose of clonazepam appeared lower for group 1 patients than for the other 2 patient groups. The number of patients with burning for less than 2 years was larger in group 1 than in the other groups. CONCLUSIONS: The results suggest that clonazepam may be helpful in burning mouth syndrome, inasmuch as 70% of patients (groups 1 and 2) experienced pain reduction with effects at low doses. These findings suggest that the mechanism of action of clonazepam may be specific and separate from the anxiolytic effect of the benzodiazepines and that clonazepam may represent a useful therapy in a subset of patients with burning mouth syndrome. Double-blind, placebo-controlled trials are warranted.

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药物

氯硝西泮