色氨酸和5-hydroxytryptophan萧条。
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肖K,特纳J,德尔C
色氨酸和5-hydroxytryptophan萧条。
科克伦数据库系统启2002;(1):CD003198。
- PubMed ID
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11869656 (在PubMed]
- 文摘
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背景:美拉托宁5羟基色氨酸(5-HTP)和色氨酸是所谓自然替代传统抗抑郁药,用于治疗单极抑郁和情绪障碍。目的:确定5-HTP和色氨酸比安慰剂更有效,和他们是否安全使用治疗抑郁障碍的成年人。搜索策略:试验在计算机通用搜索(Psychlit, Medline和Embase)和专业数据库(Cochrane协作网Cochrane控制临床试验注册,抑郁,焦虑和神经症对照试验注册);通过检查参考相关文章列表;通过handsearching相关专业期刊;在适当的地方,通过联系相关作者。出版物在所有语言。选择标准:试验包括如果他们被随机分配,包括单极抑郁或精神抑郁患者,准备5-HTP或色氨酸与安慰剂相比,包括临床结果评估量表评估抑郁症状。数据收集和分析:由三个审稿人,独立提取数据到数据收集形式。入选标准是适用于所有潜在的独立研究和协议(κ)系数计算。 Disagreement was resolved by reaching consensus. Trial quality was scored according to risk of bias. Analysis for 5-HTP and tryptophan were combined due to the small number of included trials. MAIN RESULTS: 108 trials were located using the specified search strategy. Of these, only two trials, involving a total of 64 patients, were of sufficient quality to meet inclusion criteria. The available evidence suggests these substances were better than placebo at alleviating depression (Peto Odds Ratio 4.10; 95% confidence interval 1.28-13.15; RD 0.36; NNT 2.78). However, the evidence was of insufficient quality to be conclusive. REVIEWER'S CONCLUSIONS: A large number of studies appear to address the research questions, but few are of sufficient quality to be reliable. Available evidence does suggest these substances are better than placebo at alleviating depression. Further studies are needed to evaluate the efficacy and safety of 5-HTP and tryptophan before their widespread use can be recommended. The possible association between these substances and the potentially fatal Eosinophilia-Myalgia Syndrome has not been elucidated. Because alternative antidepressants exist which have been proven to be effective and safe the clinical usefulness of 5-HTP and tryptophan is limited at present.
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