在老鼠身上Oleoyl-estrone诱发身体脂肪的损失。

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山崎D, F Balada,德尔的乳制品,Virgili J, Peinado J,蒙特塞拉特C, Fernandez-Lopez是的,Remesar X, Alemany M

在老鼠身上Oleoyl-estrone诱发身体脂肪的损失。

Int J ob过热金属底座Disord。1996年6月,20 (6):588 - 94。

PubMed ID

8782737 (在PubMed

]

文摘

目的:四个实验设计测试雌激素酮脂肪酸酯为脂肪组织的可能作用信号由血液内脂蛋白。设计:Oleoyl-estrone合成和融入脂质体;管理的增长值(模仿脂蛋白交付)14天时间使用植入式渗透微型泵。血液中发现的研究包括oleoyl-estrone脂蛋白,相关性的影响体重剂量和oleoyl-estrone标签的组织,其内化和处置。主题:正常体重纯种雌性率。汇集人类血液被用作HDL3来源。测量:Oleoyl-estrone被发现在老鼠的白色脂肪组织和人类血液HDL3脂蛋白分数。体重的变化,食物摄入量、耗氧量、呼吸商和氮平衡测定长期注射大鼠。由组织的吸收和水解oleoyl-estrone也决定急性后管理。结果:Oleoyl-estrone诱导剂量依赖性的重量损失,减少食物的摄入量。 In 14 days, and compared with controls at the end of this period, a dose of 0.78 mumol/day induced the loss of 16.4 +/- 5.5% of body weight; the difference was maximal for doses of 15 mumol/day or higher: 24.7 +/- 3.1%. Under oleoyl-estrone treatment, body protein was preserved (positive nitrogen balances) and fat stores were wasted: lowered respiratory quotient, and deficit in energy balance; a dose of 0.78 mumol/day induced the loss of 9.6 +/- 2.2 g of total body lipids in 14 days. Most of oleoyl-estrone taken up by tissues was hydrolysed; however, in part it reached intact the cell nucleus of incubated adipocytes. Oleoyl-estrone effects were different from those of free estrone. CONCLUSION: A lipophilic pathway for oleoyl-estrone transport by lipoproteins is postulated, allowing chemical communication between tissues. Oleoyl-estrone may be directly involved in the control of body weight.

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药物

Oleoyl-estrone