局部becocalcidiol治疗牛皮癣寻常的:一项随机,安慰剂对照,双盲、多中心研究。

文章的细节

引用

复制到剪贴板

海尔瑞迟年Kang年代,汉密尔顿助教,vooorhees JJ

局部becocalcidiol治疗牛皮癣寻常的:一项随机,安慰剂对照,双盲、多中心研究。

Br北京医学。2007年8月,157 (2):369 - 74。Epub 2007年6月26日。

PubMed ID

17596167 (在PubMed

]

文摘

背景:Becocalcidiol是维生素D(3)模拟没有血钙过多或显著刺激引起的临床前试验。目的:评价两种给药方案的疗效和安全性becocalcidiol软膏(低剂量= 75 microg g(1)每天一次8周;高剂量= 75 microg g(1)连续8周)每天两次plaque-type牛皮癣的治疗。方法:一百八十五例慢性plaque-type银屑病影响2 - 10%的身体表面积参加了多中心、双盲、与这些相应平行的组织,vehicle-controlled,随机对照试验比较局部应用安慰剂,becocalcidiol 75 microg g(1)每天一次(低剂量)或becocalcidiol每天两次(高剂量)8周。主要成果包括内科医生的静态全局整体损伤严重程度的评估(PGA)得分;牛皮癣症状严重程度(PSS)得分;不良事件;和实验室评估。结果:8周后intent-to-treat人群,高剂量becocalcidiol在统计学上优于汽车[P = 0.002;95%可信区间(CI) 6.7 - -32.2), 61年16(26%)对象实现PGA得分清楚或几乎清晰。 Greater improvement in PSS score was seen with high-dose becocalcidiol than with vehicle, but this result did not quite achieve statistical significance (P = 0.052; 95% CI -16.2 to 0.1). In all groups, therapy was safe and well tolerated, with fewer subjects experiencing irritation than is reported in studies using calcipotriol. CONCLUSIONS: Treatment with high-dose topical becocalcidiol for 8 weeks led to almost or complete clearing of moderate plaque-type psoriasis in over a quarter of patients. Therapy was safe and well tolerated.

beplay体育安全吗DrugBank数据引用了这篇文章

药物

Becocalcidiol