非盲的耐受性和疗效研究铝sesquichlorohydrate局部泡沫在腋窝和手掌多汗。
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Innocenzi D,另一个,弗兰切斯科尼L, Lacarrubba F, Nardone B, Micali G
非盲的耐受性和疗效研究铝sesquichlorohydrate局部泡沫在腋窝和手掌多汗。
北京医学。2008;21增刊1:S27-30。doi: 10.1111 / j.1529-8019.2008.00199.x。
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18727813 (在PubMed]
- 文摘
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主多汗(PH)是一种障碍,其特征是过度分泌腺的汗腺生产,主要涉及叶腋以及手掌和脚底。普通一线局部治疗PH值由铝盐(如),身体阻止外分泌腺的汗腺导管。然而,主要的刺激性接触性皮炎是一种常见的副作用的治疗。最近,一个新的低残渣,thermophobic泡沫配方含有20%铝sesquichlorohydrate了(Nidrox Mipharm波斯公司)。评估当地的耐受性和疗效20%的泡沫铝sesquichlorohydrate治疗腋窝和手掌博士二十科目受PH值参与了一项多中心、非盲的研究。当地耐受性评价医生评估瘙痒,燃烧,皮肤过敏使用四点得分(从0:没有症状3:严重的症状)。皮肤过敏与视觉量化评分。疗效评估通过小测试成绩使用四点分数(范围0 - 3)。泡沫用于清洁干燥的皮肤,每天晚上在前2周,每周3次在接下来的两周。临床评估进行基线,在第14天至28天。 Patients were monitored throughout the study for adverse events. All 20 subjects completed the study. The foam induced a significant reduction of the Minor score in comparison with baseline values (p = 0.0002) both at day 14 and at day 28. At the end of the 4-week treatment period, the foam reduced eccrine sweating by 61% (Minor score: 3.3 vs. 8.5). No skin irritation was observed during the trial except for one subject who experienced a mild and transient itching sensation. No other side effects were reported during the study. This new foam appears to be an effective and well-tolerated topical treatment in reducing sweating in patients with axillary and palmar PH.
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