脑膜瘤:68 ga-dotatoc的比较研究,68年ga-dotanoc和68年ga-dotatate分子成像的老鼠。

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Soto-Montenegro ML, Pena-Zalbidea年代,Mateos-Perez JM, Oteo M,罗梅罗E, Morcillo MA Desco M

脑膜瘤:68 ga-dotatoc的比较研究,68年ga-dotanoc和68年ga-dotatate分子成像的老鼠。

《公共科学图书馆•综合》。2014年11月4日;9 (11):e111624。doi: 10.1371 / journal.pone.0111624。eCollection 2014。

PubMed ID

25369268 (在PubMed

]

文摘

目的:本研究的目的是比较肿瘤吸收动力学和诊断价值的三个(68)Ga-DOTA-labeled生长抑素类似物(Ga-DOTATOC (68), (68) Ga-DOTANOC,和(68)Ga-DOTATATE)使用PET / CT与皮下脑膜瘤异种移植小鼠模型。方法:实验进行16男性裸体ν/ν轴承异种移植小鼠的脑膜瘤细胞系(ch - 157 mn)。(68)Ga-DOTATOC Ga-DOTANOC(68),(68)中Ga-DOTATATE FASTLab自动化平台。成像进行Argus小动物PET / CT扫描仪。SUVmax肝脏和肌肉,tumor-to-liver (T / L)和tumor-to-muscle (T / M) SUV比率计算。动力学分析使用洛根图形分析two-tissue可逆区划的模型,和的体积分布(Vt)。结果:肝SUVmax和Vt和(68)Ga-DOTANOC明显高于Ga-DOTATOC(68)和(68)Ga-DOTATATE。示踪剂之间没有显著差异被发现在肿瘤SUVmax或肌肉。没有发现差异的T / L SUV比率(68年)Ga-DOTATATE (68) Ga-DOTATOC,两者都有一个比(68)Ga-DOTANOC更高的分数。T / M SUV比率明显高于与(68)(68)Ga-DOTATATE比Ga-DOTATOC和(68)Ga-DOTANOC。 The Vt for tumor was higher with (68)Ga-DOTATATE than with (68)Ga-DOTANOC and relatively similar to that of (68)Ga-DOTATOC. CONCLUSIONS: This study demonstrates, for the first time, the ability of the three radiolabeled somatostatin analogues tested to image a human meningioma cell line. Although Vt was relatively similar with (68)Ga-DOTATATE and (68)Ga-DOTATOC, uptake was higher with (68)Ga-DOTATATE in the tumor than with (68)Ga-DOTANOC and (68)Ga-DOTATOC, suggesting a higher diagnostic value of (68)Ga-DOTATATE for detecting meningiomas.

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药物

Dotatate镓ga - 68