看老:成纤维细胞崩溃和治疗意义。

文章的细节

引用

复制到剪贴板

费舍尔GJ, Varani J, vooorhees JJ

看老:成纤维细胞崩溃和治疗意义。

144年5月,拱杂志。2008 (5):666 - 72。doi: 10.1001 / archderm.144.5.666。

PubMed ID

18490597 (在PubMed

]

文摘

皮肤外表年龄的一个主要指标。在过去的十年中,已经取得了实质性的进展了解人类皮肤老化的潜在机制。这种理解当前的使用提供了依据和新开发抗衰老的治疗。我们的目标是评估当前最先进的知识与机制参与皮肤老化,与特定的专注于真皮胶原蛋白矩阵。皮肤老化的主要功能是分散的真皮胶原蛋白矩阵。分裂的结果的行为特定的酶(基质金属蛋白酶),会损害皮肤的结构完整性。生产和组织的成纤维细胞胶原蛋白矩阵不能附着在支离破碎的胶原蛋白。附件损失防止成纤维细胞接收机械信息从他们的支持,他们崩溃。拉伸是至关重要的正常平衡生产胶原蛋白和collagen-degrading酶。岁的皮肤,坍塌成纤维细胞产生低水平的胶原蛋白和高水平的collagen-degrading酶。 This imbalance advances the aging process in a self-perpetuating, never-ending deleterious cycle. Clinically proven antiaging treatments such as topical retinoic acid, carbon dioxide laser resurfacing, and intradermal injection of cross-linked hyaluronic acid stimulate production of new, undamaged collagen. Attachment of fibroblasts to this new collagen allows stretch, which in turn balances collagen production and degradation and thereby slows the aging process. Collagen fragmentation is responsible for loss of structural integrity and impairment of fibroblast function in aged human skin. Treatments that stimulate production of new, nonfragmented collagen should provide substantial improvement to the appearance and health of aged skin.

beplay体育安全吗DrugBank数据引用了这篇文章

药物

Azficel-T