Tianeptine。回顾其药效学和药代动力学特性,治疗效果在抑郁和焦虑和抑郁共存。

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王尔德MI,苯菲尔P

Tianeptine。回顾其药效学和药代动力学特性,治疗效果在抑郁和焦虑和抑郁共存。

药。1995年3月,49 (3):411 - 39。

PubMed ID

7774514 (在PubMed

]

文摘

Tianeptine是一种新型的抗抑郁剂,结构修改(三环)和药效学的概要文件。与其他抗抑郁剂,tianeptine刺激的5 -羟色胺(5 -羟色胺;5)在大鼠大脑突触体和老鼠和人类血小板增加5-hydroxyindoleacetic酸(5-HIAA)在大脑组织和血浆水平,并减少serotonergic-induced行为。Tianeptine减少肾上腺反应压力,抵销应激行为赤字和防止脑形态学的变化。tianeptine的抗抑郁疗效,如2所示的试验抑郁症或双相情感障碍抑郁患者有或没有忧郁症,大于安慰剂。抑郁症患者没有忧郁症和精神特性,双相情感障碍抑郁或情绪障碍的抗抑郁疗效短期(3个月4周)tianeptine疗法似乎类似于阿米替林、丙咪嗪和氟西汀可能优于马普替林共存的患者抑郁和焦虑。轻快但是,高频的剂量阿米替林和马普替林在这些研究中使用。初步证据显示,tianeptine在内源性抑郁症患者也可能有效。进步的治疗改善与1年的观察tianeptine治疗,和长期治疗可能减少复发或复发。Tianeptine是有效治疗抑郁症的老年人和病人post-alcohol-withdrawal子组。 Tianeptine was more effective in reducing psychic anxiety than placebo in patients with major depression or depressed bipolar disorder with or without melancholia. The overall anxiolytic properties of tianeptine in patients with coexisting depression and anxiety appear to be similar to those of amitriptyline, imipramine and fluoxetine and may be superior to those of maprotiline, although submaximal dosages of amitriptyline and maprotiline were used. Studies of tianeptine in patients with primary anxiety have not been conducted. Tianeptine is well tolerated in the short (3 months) and long (up to 1 year) term. The incidence of dry mouth (38 vs 20%), constipation (19 vs 15%), dizziness/syncope (23 vs 13%), drowsiness (17 vs 10%) and postural hypotension (8 vs 3%) are greater with amitriptyline than with tianeptine. Insomnia and nightmares occur in more tianeptine than amitriptyline recipients (20 vs 7%). The relative lack of sedative, anticholinergic and cardiovascular adverse effects with tianeptine makes it particularly suitable for use in the elderly and in patients following alcohol withdrawal; these patients are known to have increased sensitivity to the adverse effects associated with psychotropic drugs.(ABSTRACT TRUNCATED AT 400 WORDS)

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药物

Tianeptine