dextran-40在人的抗血栓形成的效果是由于增强纤维蛋白溶解体内。

文章的细节

引用
复制到剪贴板

琼斯CI,佩恩哒,海耶斯PD, Naylor AR,贝尔公关,汤普森MM,古德啊

dextran-40在人的抗血栓形成的效果是由于增强纤维蛋白溶解体内。

J Vasc Surg. 2008年9月,48(3):715 - 22所示。doi: 10.1016 / j.jvs.2008.04.008。Epub 2008年6月24日。

PubMed ID
18572351 (在PubMed
]
文摘

背景:Dextran-40是有效地降低术后Doppler-detectable栓塞的患者接受颈动脉内膜切除术(CEA)。右旋糖酐被认为是抗血栓和抗血小板效果。行动的模式尚不清楚。在老鼠、右旋糖酐块吸收组织纤溶酶原激活物(tPA) mannose-binding受体。因为这将增强内生纤维蛋白溶解的影响,我们研究了这dextran-40对纤维蛋白溶解的影响的人。方法:20例接受腹主动脉瘤血管内支架的被随机分配接受100毫升的10% dextran-40或生理盐水,超过1小时,除了肝素在他们的操作。血液样本被术前,术(后立即手术过程),术后24小时。血栓形成在钱德勒循环和用于评估内生纤维蛋白溶解在24小时内,测量血栓重量的下降,释放荧光标记的血栓的纤维蛋白原。等离子体标记纤维蛋白溶解的样品进行了分析;PAI-1 plasmin-antiplasmin (PAP),以及功能和药t - pa,血管性血友病因子(vWF)。 Platelet response to thrombin and other agonists was measured by flow cytometry. RESULTS: Thrombi formed ex vivo from the intraoperative blood samples from the dextran-treated patients exhibited significantly greater fibrinolysis vs preoperative samples, seen both as a significantly greater percentage reduction in thrombus weight (from 34.7% to 70.6% reduction) and as an 175% increase in the release of fluorescence (P < .05). Fibrinolysis returned to baseline levels the next day. No change was seen in the saline-treated group. Plasma levels of PAP and PAI-1 increased significantly postoperatively in the dextran-treated group vs the saline group (P < .05). The postoperative level of functional VWF was significantly lower in the dextran-treated group vs controls. A specific reduction occurred in the platelet response to thrombin, but not to other agonists, in the intraoperative samples from the dextran-treated group (11.1% vs 37.1%; P = .022), which was not seen in the controls. CONCLUSIONS: These data are consistent with a rise in plasmin due to dextran blockade of tPA uptake in vivo, leading to enhanced fibrinolysis, cleavage of vWF and of the platelet protease-activated receptor-1 (PAR-1) thrombin receptor. This suggests that dextran exerts a combined therapeutic effect, enhancing endogenous fibrinolysis, whilst also reducing platelet adhesion to vWF and platelet activation by thrombin. The proven antithrombotic efficacy of low-dose dextran in carotid surgery may be applicable to wider therapeutic use.

beplay体育安全吗DrugBank数据引用了这篇文章

药物
食物相互作用
药物 交互
右旋糖酐 避免与抗凝/抗血小板活动草药和补品。右旋糖酐抗血栓形成的活动,这可能会增加出血的风险,如果结合抗血小板或抗凝草药。例子包括大蒜、生姜、越桔、丹参、吡拉西坦、银杏。