北美的疗效和安全性的小说pediculicide冲洗,十四烷酸异丙酯(Resultz) 50%。
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科尔在N,帕尔马公斤,Silagy党卫军,古德曼JJ, Toole J
北美的疗效和安全性的小说pediculicide冲洗,十四烷酸异丙酯(Resultz) 50%。
J Cutan Surg. 2007; 9月- 10月11 (5):161 - 7。doi: 10.2310 / 7750.2007.00045。
- PubMed ID
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17942025 (在PubMed]
- 文摘
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背景:头虱感染是主要公害学龄儿童和是一个世界性的公共卫生问题。人们越来越担心目前的治疗的有效性由于增加阻力,安全,病beplayapp人不服从。一个安全、易用、有效的选择是必要的。目的:pediculicide冲洗,50%十四烷酸异丙酯(IPM),评估在两个在北美进行第二阶段试验。第一个试验(的概念)是一个非随机试验比较器在温尼伯,加拿大。第二次试验中,在美国进行的,是一个evaluator-blinded,随机优势试验比较50% IPM冲洗和积极控制(去掉;除虫菊酯0.33%,胡椒基丁醚4%)。主要终点是确定50%的安全性和有效性IPM作为pediculicide冲洗。方法:受试者入选标准是上述试验中会见治疗后的疗效终点7和14天。受试者还评估天0,7、14、21红斑和水肿使用修改后的眼刺激规模。 Other comments associated with the safety evaluation (ie, pruritus) were collected. RESULTS: IPM was found to be effective in the proof of concept study and comparator trial using a positive control. IPM was also well tolerated, with minimal adverse events. All adverse events were mild, resolving by completion of the study. CONCLUSION: Data suggest that IPM is a safe and effective therapy for the treatment of head lice in children and adults. IPM's mechanical mechanism of action makes development of lice resistance unlikely.
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