外消旋的肾上腺素相比,舒喘灵与毛细支气管炎住院儿童;随机对照临床试验[ISRCTN46561076]。

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兰利JM,史密斯MB,勒布朗JC, Joudrey H, Ojah CR, Pianosi P

外消旋的肾上腺素相比,舒喘灵与毛细支气管炎住院儿童;随机对照临床试验[ISRCTN46561076]。

BMC Pediatr。2005年5月5日,5 (1):7。doi: 10.1186 / 1471-2431-5-7。

PubMed ID

15876347 (在PubMed

]

文摘

背景:毛细支气管炎是最常见的引起下呼吸道疾病的初级阶段,似乎和住院率增加在加拿大和美国。吸入β受体激动剂只提供适度的短期改善。外消旋肾上腺素的试验表明冲突的结果。我们试图确定细支气管炎住院期间外消旋肾上腺素管理改善呼吸窘迫,是安全的,缩短了住院时间。方法:该研究是一项随机、双盲对照试验的雾化外消旋肾上腺素相比,舒喘灵每4小时进行一次在之前6周或< = 2岁儿童年龄与毛细支气管炎住院。主要结果是症状改善的呼吸窘迫评估工具(RDAI);二次结果住院的长度,不良事件和报告的症状一周后放电通过结构化的父母的电话面试。结果:62名儿童的平均年龄6.4个月被录取;80%的儿童呼吸道合胞体病毒(RSV)。外消旋肾上腺素导致显著改善气喘和总RDAI得分2和整个天(p < 0.05)。 The mean LOS in the epinephrine arm was 2.6 days (95% CI 2, 3.2) v. 3.4 days in those in the salbutamol group (95% CI 2.6, 4.2) (p > 0.05). Adverse events were not significantly different in the two arms. At one week post-discharge, over half of parents reported that their child still had a respiratory symptom and 40% had less than normal feeding. CONCLUSION: Racemic epinephrine relieves respiratory distress in hospitalized infants with bronchiolitis and is safe but does not abbreviate hospital stay. Morbidity associated with bronchiolitis as identified by parents persists for at least one week after hospital discharge in most infants.

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药物

Racepinephrine