化学预防结肠癌organosulfur致癌的化合物。
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Reddy BS,饶简历,Rivenson Kelloff G
化学预防结肠癌organosulfur致癌的化合物。
实用癌症杂志1993年8月1;53 (15):3493 - 8。
- PubMed ID
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8339252 (在PubMed]
- 文摘
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据报道,一些天然和合成organosulfur相关化合物起到chemopreventive作用在几个靶器官在啮齿动物模型。chemopreventive行动的40和80%最大耐受剂量(MTD)的organosulfur化合物,即茴香脑trithione,己二烯二硫化,n -乙酰半胱氨酸常和牛磺酸,在ain - 76 a的饮食管理,azoxymethane(急性中耳炎)全身肿瘤男性F344大鼠进行调查。此外,这些代理的影响二期酶的活动,即谷胱甘肽S-transferase(销售税),NAD (P) H-dependent醌还原酶,和UDP-glucuronosyl转移酶,在肝脏和结肠粘膜和肿瘤评估。茴香脑的MTD水平trithione,己二烯二硫化,n -乙酰半胱氨酸常和牛磺酸测定男性F344大鼠,发现是250,250,1500,和1500 ppm。在5周的年龄、喂养动物控制饮食(ain - 76 a)或实验饮食包含40或80% MTD水平的每个测试代理。所有的动物在每一组中,除规定车辆(生理盐水)治疗,是管理急性中耳炎南卡罗来纳州的剂量率15毫克/公斤体重一旦每周2周。所有动物尸体剖检在52周中在第二次中耳炎注入。结肠粘膜和肿瘤和肝酶活性测定在动物喂食80% MTD水平的每个测试代理。结肠肿瘤受到组织病理学评价和分类为侵入性或非侵害的腺癌。结肠肿瘤发病率(动物肿瘤的比例)和多重性肿瘤(肿瘤/动物)比较在各种饮食组。 The results indicated that administration of 200 ppm (80% MTD) anethole trithione significantly inhibited the incidence and multiplicity of both invasive and noninvasive adenocarcinomas, whereas feeding of 100 ppm (40% MTD) anethole trithione or 100 (40% MTD) or 200 ppm (80% MTD) diallyl disulfide suppressed only invasive adenocarcinomas of the colon. Although diets containing N-acetylcysteine and taurine inhibited colon tumor multiplicity, the effect was somewhat marginal. GST, NAD-(P)H-dependent quinone reductase, and UDP-glucuronosyl transferase activities in colonic mucosa and tumor and liver were significantly elevated in animals fed anethole trithione or diallyl disulfide, compared to those fed the control diet. N-Acetylcysteine and taurine slightly but significantly increased only the GST activity in the liver. Although other mechanisms are not excluded, inhibition of AOM-induced colon carcinogenesis by anethole trithione and diallyl disulfide may be associated, in part, with increased activities of phase II enzymes such as GST, NAD(P)H-dependent quinone reductase, and UDP-glucuronosyl transferase in the liver and colon.
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