AMC / DCBA含片喉咙痛的疗效:一项系统回顾和荟萃分析。

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Weckmann G, Hauptmann-Voss,鲍迈斯特,克洛茨C, Chenot摩根富林明

AMC / DCBA含片喉咙痛的疗效:一项系统回顾和荟萃分析。

Int中国Pract。2017年10月,71 (10)。doi: 10.1111 / ijcp.13002。Epub 2017年9月4。

PubMed ID
28869700 (在PubMed
]
文摘

背景:含片含Amylmetacresol和2,4-Dichlorobenzylalcohol(但是Strepsils AMC / DCBA,如((R)))销售作为治疗急性咽喉痛。这个处方配方有杀菌和局部麻醉品质。目的:系统回顾和荟萃分析的目的是评估的有效性和安全性AMC / DCBA与急性无并发症相关疼痛的缓解喉咙痛。方法:系统回顾文献进行了使用数据库Medline、Embase和Cochrane识别随机对照试验比较AMC / DCBA与安慰剂或替代当地治疗方案对急性简单的喉咙痛。一个额外的手进行搜索。两个评论者独立评估引用相关性、入选标准和风险的偏见。荟萃分析进行了试验和标准化意味着差异(SMD;dCohen)和95%的置信区间(CIs)计算。结果:文献检索了77年引文3满足入选标准。AMC / DCBA含片(0.6 mg Amylmetacresol, 1.2毫克4-Dichlorobenzylalcohol)是与unflavoured相比,non-medicated含片。 The AMC/DCBA formulation additionally contained lidocaine in one and flavouring additives in another trial. A total of 660 adults participated in the included trials. Primary outcome was reduction in pain intensity against baseline, 2 hours after intervention compared with placebo group. Fixed effects meta-analysis resulted in a standardised mean difference in pain intensity of -0.6 (-0.75; -0.45) on an 11-point ordinal rating scale, favouring the AMC/DCBA lozenges. Secondary outcomes were sore throat relief, difficulty swallowing and throat numbness. No serious side effects were reported, whereas mild side effects like headache, cough, nasal congestion and irritation of the oral cavity, were reported in up to 16% of subjects in both groups. All included trials were sponsored by a manufacturer of AMC/DCBA containing lozenges. CONCLUSIONS: Lozenges with AMC/DCBA can be a safe treatment option to relieve pain in patients with uncomplicated sore throat looking for local treatment options and valuing the modest additional effect compared with non-medicated lozenges. Registration: PROSPERO CRD42015008826.

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