对照试验精神病学的肌醇。

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莱文J

对照试验精神病学的肌醇。

Neuropsychopharmacol欧元。1997年5月,7 (2):147 - 55。

PubMed ID
9169302 (在PubMed
]
文摘

肌醇是一个简单的多羟基化合物前体在第二信使系统重要的大脑中。脑脊液肌醇被报道为减少抑郁。双盲对照试验12 g每日28抑郁症患者的肌醇4周。重要的整体利益为肌醇与安慰剂相比被发现在星期4汉密尔顿抑郁量表。没有在血液学变化、肾脏或肝脏功能。因为很多抗抑郁药物是有效的在恐慌症,有或没有广场恐慌症患者21完成了一项双盲,安慰剂对照,治疗4周,随机分配交叉试验的肌醇每天12克。恐慌症发作的频率和严重程度和严重程度的广场恐怖症和肌醇与安慰剂相比显著下降。副作用最小。自从5 -羟色胺再吸收抑制剂有利于强迫症(OCD)和肌醇据报道,反向脱敏的5 -羟色胺受体,十三个强迫症患者完成了双盲交叉试验18 g肌醇或安慰剂控制六个星期。肌醇与安慰剂比较,显著降低分数强迫症的症状。 A controlled double-blind crossover trial of 12 g daily of inositol for a month in twelve anergic schizophrenic patients, did not show any beneficial effects. A double-blind controlled crossover trial of 6 g of inositol daily vs. glucose for one month each was carried out in eleven Alzheimer patients, with on clearly significant therapeutic effects. Antidepressant drugs have been reported to improve attention deficit disorder (ADDH) with hyperactivity symptomatology. We studied oral inositol in children with ADDH in a double-blind, crossover, placebo-controlled manner. Eleven children, mean age 8.9 +/- 3.6 years were enrolled in an eight week trial of inositol or placebo at a dose of 200 mg/kg body weight. Results show a trend for aggravation of the syndrome with myo-inositol as compared to placebo. Recent studies suggest that serotonin re-uptake inhibitors are helpful in at least some symptoms of autism. However a controlled double-blind crossover trial of inositol 200 mg/kg per day showed no benefit in nine children with autism. Cholinergic agonists have been reported to ameliorate electroconvulsive therapy (ECT)-induced memory impairment. Inositol metabolism is involved in the second messenger system for several muscarinic cholinergic receptors. Inositol 6 g daily was given in a crossover-double-blind manner for five days before the fifth or sixth ECT to a series of twelve patients, without effect. These results suggest that inositol has therapeutic effects in the spectrum of illness responsive to serotonin selective re-uptake inhibitors, including depression, panic and OCD, and is not beneficial in schizophrenia, Alzheimer's ADDH, autism or ECT-induced cognitive impairment.

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