项研究来自评估草莓口味和桔子味的可接受性amylmetacresol / 2, 4-dichlorobenzyl酒精在健康儿童喉糖。

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汤普森,读者年代,E,谢泼德

项研究来自评估草莓口味和桔子味的可接受性amylmetacresol / 2, 4-dichlorobenzyl酒精在健康儿童喉糖。

药物R d . 2013年6月,13 (2):101 - 7。doi: 10.1007 / s40268 - 013 - 0012 - x。

PubMed ID
23588685 (在PubMed
]
文摘

背景:急性咽喉痛(咽炎)是最常见的一种疾病,孩子被初级护理医师。大多数情况下是由病毒引起的,是良性自限性。临床证明,场外喉糖提供迅速和有效缓解急性咽喉痛症状,在自我管理和越来越重要的条件。摘要目的:本研究的目的(国际标准随机对照试验号:ISRCTN34958871)的可接受性评价两个许可,商用润喉片含有amylmetacresol和2,4-dichlorobenzyl (AMC / DCBA)——一个草莓味和其他橙味——在健康儿童。研究设计:这是一个非盲、单剂量交叉,来自研究招募儿童通过临床数据库和在3.5周期间的广告。设置:潜在的合格的参与者被邀请去参加来自会话的一家诊所。参与者:在筛选会话发生之前或当天口味测试、相关病史的细节,药物,和人口统计记录。108年上映,102年被招募。这些都是健康男性和女性的6 - 12岁的儿童。干预:每个孩子洁净水和饼干的口感和之前品尝草莓口味菱形(但是Strepsils (R)草莓无糖,利洁时公司医疗有限,诺丁汉,英国; PL 00063/0395), which was sucked for 1 minute and then expelled. The orange-flavored lozenge (Strepsils(R) orange with vitamin C, Reckitt Benckiser Healthcare Limited, Nottingham, UK; PL 016242152) was tasted at least 15 minutes later following further cleansing of the palate. The spontaneous reaction of the child on tasting each lozenge was observed and recorded. Subjects were asked to indicate their liking for each lozenge, using a 7-point hedonic facial scale, and were required to answer a series of questions relating to what they liked and disliked about the taste and the feel of the lozenge in the mouth and throat. The primary endpoint was the proportion of subjects with a hedonic facial score of >4. Secondary endpoints included the spontaneous reaction of the child on tasting the lozenge and responses to questions related to taste. RESULTS: The taste of the lozenge was scored >4 (i.e. 'good', 'really good', or 'super good') by 85.3% of subjects for the strawberry flavor and 49.0% for the orange flavor (p < 0.0001). The mean (standard deviation) score was 5.72 (1) for the strawberry-flavored lozenge and 4.35 (2) for the orange-flavored lozenge. The proportion of subjects willing to take the lozenge again was 94% for the strawberry flavor and 56% for the orange flavor. CONCLUSIONS: Strawberry-flavored AMC/DCBA lozenges were liked by, and acceptable to, the majority of the children. AMC/DCBA orange-flavored lozenges were also liked by, and acceptable to, approximately half the children. Overall, both strawberry and orange would be suitable flavors for lozenges intended for children when they suffer from sore throat.

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