Acetarsol栓剂:有效治疗难治性直肠炎患者的炎症性肠病。

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基利CJ,克拉克,Bhattacharyya J,莫兰GW,李JC, Parkes M

Acetarsol栓剂:有效治疗难治性直肠炎患者的炎症性肠病。

挖说科学。2018年4月,63 (4):1011 - 1015。doi: 10.1007 / s10620 - 017 - 4890 - 6。Epub 2018年2月19日。

PubMed ID

29457211 (在PubMed

]

文摘

背景:对常规治疗直肠炎耐火材料管理提出了一种常见的临床问题。使用acetarsol栓剂,来源于有机砷,于1965年第一次描述了。有关临床疗效和耐受性的资料非常有限。目的:检验的功效acetarsol栓剂治疗难治性直肠炎。方法:回顾性分析患者炎症性肠病治疗acetarsol栓剂阿登布鲁克医院2008年至2014年之间,英国剑桥。症状的临床反应定义为决议回到基线下诊所复查的时候。结果:39例规定acetarsol栓剂2008年3月至2014年7月(29溃疡性结肠炎患者,9克罗恩氏病,和一个不确定的结肠炎)。38包括进行分析。acetarsol的标准剂量是每天两次250毫克/直肠为4周。临床反应是观察26例(68%)。 Of the 11 patients who had endoscopic assessment before and after treatment, nine (82%) showed endoscopic improvement and five (45%) were in complete remission (Wilcoxon signed-rank test p = 0.006). One patient developed a macular skin rash 1 week after commencing acetarsol, which resolved within 4 weeks of drug cessation. CONCLUSION: Acetarsol was effective for two out of every three patients with refractory proctitis. This cohort had failed a broad range of topical and systemic treatments, including anti-TNFalpha therapy. Clinical efficacy was reflected in significant endoscopic improvement. Adverse effects of acetarsol were rare.

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Acetarsol