比较口服剂量硒化合物的毒性动力学在硒蓄电池工厂随处可见。

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戴维斯TZ, Stegelmeier提单,韦尔奇KD,斯杰,裤子KE,乔

比较口服剂量硒化合物的毒性动力学在硒蓄电池工厂随处可见。

J动物科学。2013年9月,91 (9):4501 - 9。doi: 10.2527 / jas.2012 - 6101。Epub 2013 7月3。

PubMed ID

23825349 (在PubMed

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文摘

消费Se蓄电池工厂的牲畜可能导致中毒。最近的研究表明,硒形式最常见在Se硒酸蓄电池工厂和Se-methylselenocysteine (MeSeCys)。在这项研究的吸收、分布和消除动力学Se在血清和全血的羊羔给单剂量口服(1、2、3或4毫克Se /公斤BW)硒酸钠或MeSeCys测定。Se在血清和全血浓度的化学形式的Se后简单的剂量依赖性关系。Se-methylselenocysteine吸收更迅速和更大程度上在全血硒酸钠相比,所观察到的更大的峰值Se浓度(Cmax;P < 0.0001),和更快的浓度峰值时间(达峰时间;P < 0.0001)和吸收速率(P < 0.0001)。吸收的速率和最高温度也快(P < 0.0001),血清的羊羔给MeSeCys克分子数相等的剂量与给硒酸钠;然而,Cmax血清中更大(P < 0.0001)和硒酸钠与羊羔给那些给MeSeCys克分子数相等的剂量。吸收了MeSeCys快4到5倍成血清和9到14倍全血克分子数相等的Se剂量。 There were dose-dependent increases in the area under the curve (AUC) for Se in serum and whole blood of lambs dosed with both sodium selenate and MeSeCys. In whole blood the MeSeCys was approximately twice as bioavailable as sodium selenate at equimolar doses as observed by the AUC, whereas in serum there were no differences (P > 0.05) in AUC at the same doses. At 168 h postdosing the Se concentration in whole blood remained much greater (P < 0.0001) in lambs dosed with MeSeCys as compared with lambs dosed with sodium selenate; however, the serum Se concentrations were not different between treatments at the same time point. The results presented in this study demonstrate that there are differences between the kinetics of different selenocompounds when orally dosed to sheep. Therefore, in cases of acute selenosis, it is important to understand the chemical form to which an intoxicated animal was exposed when determining the importance and meaning of Se concentration in serum or whole blood obtained at various times postexposure.

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