薄荷油治疗肠易激综合症:系统回顾和荟萃分析。

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Khanna R,麦克唐纳JK,几何BG

薄荷油治疗肠易激综合症:系统回顾和荟萃分析。

中国新药杂志。2014年7月,48(6):505 - 12所示。doi: 10.1097 / MCG.0b013e3182a88357。

PubMed ID

24100754 (在PubMed

]

文摘

目标:本研究的目的是评估肠溶薄荷油胶囊的有效性和安全性与安慰剂比较治疗肠易激综合征(IBS)的活跃。背景:肠易激综合症是一种常见的疾病,在临床实践中经常遇到。医疗干预措施是有限的,重点是控制症状。研究:随机安慰剂对照临床试验的最低治疗2周时间被认为是包含。交叉研究提供了第一个交叉包括之前的结果数据。文献搜索到2013年2月确定所有适用的随机对照试验。研究质量使用Cochrane偏见的风险评估工具。结果包括全球改善IBS症状,改善腹痛,不良事件。使用意向性治疗方法的结果进行了分析。结果:九评估726名患者的研究发现。 The risk of bias was low for most of the factors assessed. Peppermint oil was found to be significantly superior to placebo for global improvement of IBS symptoms (5 studies, 392 patients, relative risk 2.23; 95% confidence interval, 1.78-2.81) and improvement in abdominal pain (5 studies, 357 patients, relative risk 2.14; 95% confidence interval, 1.64-2.79). Although peppermint oil patients were significantly more likely to experience an adverse event, such events were mild and transient in nature. The most commonly reported adverse event was heartburn. CONCLUSIONS: Peppermint oil is a safe and effective short-term treatment for IBS. Future studies should assess the long-term efficacy and safety of peppermint oil and its efficacy relative to other IBS treatments including antidepressants and antispasmodic drugs.

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药物

薄荷油