细菌学的评价醋酸麦迪霉素及其代谢物。

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渡边吉田T, T, Shomura T, S,染谷伸一说Okamoto R,石原年代,Miyauchi K, Kazuno Y

细菌学的评价醋酸麦迪霉素及其代谢物。

日本J Antibiot。1982年6月,35 (6):1462 - 74。

PubMed ID

6982352 (在PubMed

]

文摘

体外醋酸麦迪霉素被证明有广谱的抗菌活性与其他大环内酯类(麦迪霉素、交沙霉素、9-propionyl交沙霉素和2“-ethylsuccinyl红霉素),其中包括革兰氏阳性生物体,革兰氏阴性细菌和厌氧生物的一部分。醋酸麦迪霉素代谢物也显示出一定程度的抗菌活性虽然他们给比醋酸麦迪霉素更高的MIC值。醋酸麦迪霉素的抗菌活性强的介质酸度7或8和小受培养液大小或人类血清中。醋酸麦迪霉素及其代谢物有相对较高的蛋白结合率。体内治疗实验在实验感染小鼠醋酸麦迪霉素被证明更优于其他药物进行治疗效果与腹腔内由金黄色葡萄球菌引起的感染。葡萄球菌,Strept。化脓性链球菌,Strept。肺炎和Cl。perfringens。在感染Strept引起的底。 pneumoniae, midecamycin acetate showed therapeutic efficacy 2 or 5 times greater than that of josamycin or midecamycin, despite that MICs of midecamycin acetate were equal to josamycin or midecamycin. Moreover, midecamycin acetate showed high therapeutic efficacy for subcutaneous infections due to Staph. aureus, suggesting that it exerts pronounced antibacterial activities against not only systemic infections but also local infections.

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药物

麦迪霉素