泊咯沙姆188体积减少大鼠神经元损失时间的方式。

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咖喱DJ,赖特哒,李RC, Kang UJ、无机玻璃钢DM

泊咯沙姆188体积减少大鼠神经元损失时间的方式。

神经外科。2004年10月;55 (4):943 - 8;讨论948 - 9。

PubMed ID

15458603 (在PubMed

]

文摘

摘要目的:会是一个多步骤的过程,导致坏死或凋亡。它与神经元有关死于创伤,缺血和神经退化。坏死细胞死亡的最后一步是细胞的质膜破裂;修复这个膜破裂是一个潜在的强大的神经保护技术。188年泊咯沙姆(p - 188)是一个合成表面活性剂,海豹实验porat膜。本研究调查的有效性和时间依赖性鞘内p - 188在保护神经元在体内会引起的大鼠模型。方法:28 Sprague-Dawley老鼠接受了纹状体注入喹啉酸生产球形excitotoxic病变。每只动物然后收到车辆或p - 188在10分钟,手术后4小时,或时间点通过直接小脑延髓池注入。动物被杀害在1周,大脑神经元标记Neu-N免疫组织化学染色。大量的神经元损失计算和比较组间方差分析。 RESULTS: All animals were found to have spherical, stereotyped lesions. The animals that received intrathecal poloxamer at the early injection time had statistically smaller lesions (8.16 +/- 6.12 mm(3); n = 5; P = 0.0015) than controls (18.25 +/- 11.42 mm(3); n = 11). Those animals that received poloxamer at both injection times also had statistically smaller lesions (10.57 +/- 9.00 mm(3); n = 7; P = 0.0095). The group that received poloxamer at the late injection time only did not have significantly decreased lesion size (14.86 +/- 7.95 mm(3); n = 5). CONCLUSION: Intrathecal P-188 reduces neuronal loss after excitotoxic injury in the rat only when delivered immediately after the toxin. This observation confirms the potential of surfactant molecules as neuroprotectants but predicts that their usefulness is best realized by early and potentially ongoing treatment.

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药物

188年泊咯沙姆