药物动力学的epanolol在老年急性和慢性口腔给药后稳定心绞痛患者。

文章的细节

引用

复制到剪贴板

Scott AK Hosie J,皮特里JC, Cockshott ID

药物动力学的epanolol在老年急性和慢性口腔给药后稳定心绞痛患者。

Br中国新药杂志。1990年3月29日(3):333 - 7。

PubMed ID

1968755 (在PubMed

]

文摘

1。Epanolol是一种新型的药物剂是β1-adrenoceptor部分激动剂表现出选择性β1-adrenoceptor拮抗剂和选择性β1-adrenoceptor受体激动剂活性。主要代谢之前配合尿液中排泄,这是确定任何感兴趣的积累发生在老年患者。2。epanolol的药物动力学研究了超过72 h 200毫克的单剂量口服后,然后在24小时后连续12 13个老年患者每日口服剂量稳定心绞痛。3所示。血浆浓度峰值(意思是南达科他州+ / -)后,单剂量(25.7 + / - 17.0 ng ml-1)没有显著差异(P = 0.35)从那些在稳态(32.4 + / - 20.9 ng ml-1)。有宽inter-individual变化两次。达到峰值的时间没有显著改变在研究平均值为1.5和1.2 h分别在急性和慢性给药。4所示。 Plasma concentrations declined biphasically with a mean terminal phase half-life of 17 h and 5 fold inter-individual variation. 5. The mean area under the curve to 24 h was not significantly different (P = 0.26) after the single dose (59.0 +/- 29.8 ng ml-1 h) from that at steady state (78.4 +/- 55.0 ng ml-1 h). There was also wide inter-individual variation in these values. 6. In conclusion, the lack of significant accumulation of epanolol indicates that no alteration of dose is necessary when using epanolol in elderly patients with normal renal and hepatic function.

beplay体育安全吗DrugBank数据引用了这篇文章

药物

Epanolol