提高痰咳痰的单剂量INS316患者慢性支气管炎。

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约翰逊FL,唐纳休摩根富林明,沙福尔CL

提高痰咳痰的单剂量INS316患者慢性支气管炎。

胸部。2002年12月,122 (6):2021 - 9。

PubMed ID

12475842 (在PubMed

]

文摘

尿苷5 '三磷酸(UTP)是一种天然为P2Y受体激动剂(2)受体的顶端表面纤毛呼吸道上皮细胞。UTP刺激盐和水运输和纤毛拍频在人类呼吸道上皮细胞体外。单身,吸入剂量的UTP在意识刺激黏膜纤毛的清除,插管绵羊和轻度慢性支气管炎患者(吸烟者和吸烟者前),这表明UTP可能是用于获取该产品适合诊断痰标本。研究目的:UTP正在开发的细胞学的诊断肺癌复合数下吸入INS316解决方案(激励药品;达勒姆,NC)。它能够提高咯血痰的质量测试在当前的研究中。设计:安慰剂对照、双盲、升级两年期交叉研究。设置:门诊志愿者。患者或参与者:26患者轻度慢性支气管炎。干预:患者自发地试图咳出痰标本,后一个吸入剂INS316(10至180毫克),和安慰剂。 MEASUREMENTS AND RESULTS: Sputum weight, sputum cell content, spirometry, and oxyhemoglobin saturation. Only 28% of these patients were able to expectorate a macrophage-containing, deep-lung specimen spontaneously or following inhalation of placebo. In contrast, 85% of the patients were able to produce a specimen following inhalation of INS316. The average weight of the sputum expectorated was increased fourfold by placebo and 10-fold by INS316. A mild transient decrease in pulmonary function was observed following INS316 administration. CONCLUSION: A single dose of INS316 safely improves the ability of patients with mild chronic bronchitis to expectorate a deep-lung sputum specimen suitable for cytologic evaluation.

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药物

INS 316