评估血浆脂质水平、体重、肝和肾毒性后长期口服的水溶性phytostanol化合物,FM-VP4,沙鼠。

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黄一公里,纳杰菲年代,J,邝M,普里查德的PH值

评估血浆脂质水平、体重、肝和肾毒性后长期口服的水溶性phytostanol化合物,FM-VP4,沙鼠。

J制药制药科学。2001 Sep-Dec; 4 (3): 228 - 34。

PubMed ID

11737988 (在PubMed

]

文摘

这个项目的目的是确定FM-VP4的影响纳入饮食或饮水时血浆脂质、体重、肝和肾功能后长期口服沙鼠。沙鼠是水和食物的日常管理包含没有FM-VP4(控制;n = 6), 2%或4% FM-VP4纳入沙鼠饮食每个治疗组(n = 6)或2%或4% FM-VP4溶解在饮用水(n = 6每个治疗组)。体重和食物和水的摄入量是每周监测。8周后获得了这团血通过心脏穿刺和所有动物都牺牲了人道。分析了等离子体得到这血总胆固醇、甘油三酯和高密度脂蛋白(HDL)胆固醇水平标准酶和沉淀技术。低密度脂蛋白(LDL)胆固醇水平取决于Friedewald方程。等离子体也分析肝酶的变化(天冬氨酸转氨酶(AST)、丙氨酸转氨酶(ALT))和血浆肌酐(肾功能)浓度。2%和4% FM-VP4管理合并到饮食和饮水导致显著降低血浆总胆固醇和低密度脂蛋白胆固醇浓度与控制。动物管理4% FM-VP4饮食或饮用水的体重有显著降低治疗8周后比其他组。 Significant differences in daily water intake was observed in all treatment groups with the exception of the 2% FM-VP4 in diet group compared to controls. Significant differences in daily food intake were observed in gerbils administered 2% FM-VP4 in the drinking water and 4% FM-VP4 in the diet and drinking water groups compared to controls. A significant decrease in total plasma triglyceride concentration was observed in gerbils administered 4% FM-VP4 in their drinking water compared to controls. A significant increase in HDL cholesterol concentrations was observed in gerbils administered 2% FM-VP4 in their diet and 4% FM-VP4 in their drinking water compared to controls. No significant elevations in AST, ALT and creatinine concentrations were reported for all treatment groups compared to controls. These findings suggest that FM-VP4 significantly decrease plasma lipids and body weight with no apparent hepatic or renal toxicity.

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药物

FM-VP4