生理和药理的褪黑激素浓度预防cisplatin-induced急性肾损伤。

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Parlakpinar H, Sahna E,沉思并可,Ozugurlu F, Vardi N,乙炔

生理和药理的褪黑激素浓度预防cisplatin-induced急性肾损伤。

J松果体研究》2002年10月,33 (3):161 - 6。

PubMed ID

12220331 (在PubMed

]

文摘

顺铂(cis-diaminedichloroplatinum (II), CDDP)是一种广泛使用的抗肿瘤药。然而,主要副作用如急性肾小管坏死(ATN)。有很多研究有关活性氧自由基的作用在CDDP-dependent ATN的病理生理学。几种抗氧化剂代理为了防止这种副作用也有报道,但没有研究关于保护性生理或药理作用的褪黑激素浓度。褪黑素,主要分泌松果体的产物,是一种自由基清除剂直接和间接的抗氧化剂。我们调查的影响褪黑激素CDDP-induced肾丙二醛(MDA)的变化,脂质过氧化作用的产品,和血液尿素氮(BUN)和血清肌酸(Cr)。肾脏的形态变化也使用光学显微镜检查。老鼠被分为两组:pinealectomized (Px)和sham-operated (non-Px)。CDDP和褪黑激素被管理的所有组。Px的MDA水平是高于non-Px动物。 CDDP administration to Px or non-Px rats increased renal MDA levels and melatonin administration either before or after CDDP injection caused significant decreases in MDA in kidney compared with those in rats treated with CDDP alone. Serum levels of BUN and Cr did not change as a result of any treatment. Morphological tubule damage because of CDDP was more severe in the renal cortex than in the medulla. The damage to the kidney induced by CDDP was reversed by melatonin. The results show that pharmacological and physiological concentrations of melatonin reduce CDDP-induced renal injury.

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atn - 161