脑静脉窦血栓形成的分子核磁共振使用新的fibrin-specific造影剂先生。

文章的细节

引用

复制到剪贴板

Stracke CP, Katoh M, Wiethoff AJ,帕森斯EC, Spangenberg P, Spuntrup E

脑静脉窦血栓形成的分子核磁共振使用新的fibrin-specific造影剂先生。

中风。2007年5月,38 (5):1476 - 81。Epub 2007年3月22日。

PubMed ID

17379818 (在PubMed

]

文摘

背景和目的:脑静脉血栓形成的成像仍具有挑战性。目前,基于CT静脉造影术和MRI诊断包括MRA和传统的数字减影血管造影。然而,特别是在长期情况下,每个方法已经显示出其局限性。更新的战略核磁共振分子成像上发现使用靶向造影剂。本研究的目的是为了证明小说fibrin-targeted MR对比剂的可行性(ep - 2104 r;EPIX(他们刚刚与药品)的选择性成像窦静脉血栓形成在动物模型。方法:上矢状窦血栓形成的与人类血液诱导6猪使用显微外科和介入方法。MRI是执行之前和120分钟后注入4 micromol ep - 2104 r /公斤体重。分子成像进行了三维高分辨率t1加权梯度回波序列。时间的信噪比和contrast-to-noise比进行了分析。 Thrombi were then surgically removed and the Gadolinium concentration was assessed. RESULTS: In all cases the thrombosis could be successfully induced; the complete MR protocol could be performed in 5 animals. In these cases the thrombi showed selective enhancement after injection of the molecular contrast agent. However, a continuous contrast-to-noise ratio increase was seen up to 120 minutes after contrast administration, achieving a contrast-to-noise ratio of 14.2+/-0.7 between clot and the blood pool. CONCLUSIONS: The novel fibrin-targeted molecular MR contrast EP-2104R allows selective and high-contrast imaging of cerebral sinus vein thrombosis in an animal model.

beplay体育安全吗DrugBank数据引用了这篇文章

药物

ep - 2104 r