选择性5 -羟色胺再摄取抑制剂(SSRIs)自闭症谱系障碍(ASD)。

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威廉姆斯K,惠勒DM, Silove N, P黑兹尔

选择性5 -羟色胺再摄取抑制剂(SSRIs)自闭症谱系障碍(ASD)。

科克伦数据库系统启2010 8月4;(8):CD004677。cd004677.pub2 doi: 10.1002/14651858.。

PubMed ID

20687077 (在PubMed

]

文摘

背景:自闭症谱系障碍(ASD)的特点是异常在社会交往和沟通技巧,以及刻板行为和限制活动和利益。选择性5 -羟色胺再摄取抑制剂(SSRIs)规定等与自闭症相关的伴随疾病的治疗抑郁、焦虑和强迫性行为。目的:确定一个SSRI治疗:1。改善自闭症的核心功能(社会互动、沟通和行为问题);2。改善其他非核心有自伤行为等方面的行为或功能;3所示。提高了孩子和他们的照顾者的生活质量;4所示。短期和长期影响的结果; 5. causes harms. SEARCH STRATEGY: We searched the Cochrane Central Register of Controlled Trials (The Cochrane Library 2009, Issue 4), MEDLINE ( December 2009), EMBASE (December 2009), CINAHL (December 2009), PsycINFO (December 2009) and ERIC (December 2009), without language restrictions. SELECTION CRITERIA: Randomised controlled trials (RCTs) of any dose of oral SSRI compared with placebo, in participants with autism spectrum disorders. Trials must have included at least one standardised outcome measure. DATA COLLECTION AND ANALYSIS: Two authors independently selected and appraised studies for inclusion and risk of bias. All data were continuous. Meta-analysis, where possible, used a random-effects model. MAIN RESULTS: Seven RCTs with a total of 271 participants were included. Four SSRIs were evaluated: fluoxetine (two studies), fluvoxamine (two studies), fenfluramine (two studies) and citalopram (one study). Five studies included only children and two studies included only adults. Varying inclusion criteria were used with regard to diagnostic criteria and intelligence of participants. Seventeen different outcome measures were reported. Although more than one study reported data for Clinical Global Impression (CGI) and obsessive-compulsive behaviour (OCB), different tool types or components of these outcomes were used in each study. As such, data were unsuitable for meta-analysis. One large, high quality study in children showed no evidence of positive effect of citalopram. Two small studies in adults showed positive outcomes for CGI and OCB; one study showed improvements in aggression and another in anxiety. AUTHORS' CONCLUSIONS: There is no evidence of effect of SSRIs in children and emerging evidence of harm. There is limited evidence of the effectiveness of SSRIs in adults from small studies in which risk of bias is unclear.

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药物靶点

药物	目标	类	生物	药理作用	行动
氟伏沙明	Sodium-dependent羟色胺转运体	蛋白质	人类	是的	抑制剂	细节