前列腺素类似物在眼压的影响前列腺素类FP-receptor-deficient老鼠。

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Ota T, Aihara M, Narumiya年代,Araie M

前列腺素类似物在眼压的影响前列腺素类FP-receptor-deficient老鼠。

角膜切削Vis Sci投资。2005年11月,46 (11):4159 - 63。

PubMed ID

16249494 (在PubMed

]

文摘

目的:本研究旨在阐明前列腺素类FP受体参与latanoprost的眼内压(IOP)降低影响,travoprost, bimatoprost, unoprostone使用FP-receptor-deficient (FPKO)老鼠。方法:FPKO和野生型小鼠(WT)培育适应12小时的光暗周期。眼压测量在全身麻醉下的微针方法:评估每种药物的影响,单一的下降(3 muL)的药物蒙面的方式的解决方案是使用一个随机选择的眼睛。眼压降低眼压的差别进行了治疗眼睛和未经处理的对侧眼在同一个鼠标。首先,日变化和基线在WT FPKO老鼠测量眼压。然后,确定展示的窗口可行最明显眼降压效果,0.005% latanoprost应用WT老鼠在白天或晚上。时眼低血压患者效果更大的被选作进一步的研究来评估latanoprost的影响(0.005%)、travoprost (0.004%)、bimatoprost(0.03%),和unoprostone (0.12%)。此外,bunazosin(0.1%)也被应用于演示功能uveoscleral流出FPKO老鼠。所有实验在一个蒙面的研究设计。结果:基线眼压(平均+ / - SEM)在WT FPKO老鼠是15.0 + / - 0.2和15.0 + / - 0.3毫米汞柱,分别在白天,和18.9 + / - 0.4和19.2 + / - 0.4毫米汞柱,分别在晚上。 In WT mice, latanoprost significantly lowered IOP both during the day and at night, at 2 to 6 hours and 1 to 6 hours after application, respectively. Maximal IOP reduction was observed at 3 hours after drug instillation both during the day (10.9 +/- 1.8%) and at night (23.2 +/- 1.1%). At 3 hours after instillation, latanoprost (10.9 +/- 1.8% and 23.2 +/- 1.1%, daytime and nighttime, respectively), travoprost (15.9 +/- 1.4% and 26.1 +/- 1.2%) and bimatoprost (8.8 +/- 2.0 and 19.8 +/- 1.5%) significantly lowered IOP in WT mice both during the day and at night; isopropyl unoprostone significantly lowered IOP at night (13.7 +/- 1.9%) but not during the day (5.3 +/- 3.2%). In FPKO mice, latanoprost, travoprost, bimatoprost, and unoprostone showed no significant IOP-lowering effect. Bunazosin significantly lowered IOP in both WT (22.1 +/- 1.6%) and FPKO mice (22.2 +/- 2.1%). CONCLUSIONS: A single application of latanoprost, travoprost, bimatoprost, or unoprostone had no effect on IOP in FPKO mice with presumed functional uveoscleral outflow pathways. The prostanoid FP receptor plays a crucial role in the mechanism of early IOP lowering of all commercially available prostaglandin analogues.

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药物靶点

药物	目标	类	生物	药理作用	行动
Travoprost	前列腺素F2-alpha受体	蛋白质	人类	是的	受体激动剂	细节