氨甲环酸:回顾它的使用在手术和其他迹象。

文章的细节

引用

复制到剪贴板

邓恩CJ,果阿吉隆坡

氨甲环酸:回顾它的使用在手术和其他迹象。

药。1999年6月,57 (6):1005 - 32。

PubMed ID

10400410 (在PubMed

]

文摘

氨甲环酸是一种氨基酸赖氨酸的合成衍生物,对其治疗效果通过可逆的封锁赖氨酸对纤溶酶原分子物结合位点。静脉注射氨甲环酸(通常10毫克/公斤随后注入1毫克/公斤/小时)引起的减少相对于安慰剂29 - 54%接受心脏手术的患者术后血液损失与心肺分流术(CPB),具有统计上显著的减少输血需求在一些研究。氨甲环酸有相似功效抑肽酶2 x 10(6)激肽释放酶抑制单位(桥)和减少术后血液中优于双嘧达莫的损失。输血需求与氨甲环酸显著减少了43%和60%与抑肽酶1的研究。60试验的荟萃分析显示氨甲环酸和抑肽酶,与epsilon-aminocaproic酸(EACA)和去氨加压素,显著减少患者的数量需要同种异体输血与体外循环心脏手术后。氨甲环酸与减少5到54%的死亡率相对于安慰剂患者上消化道出血。荟萃分析显示40%的减少。减少34 - 57.9%和安慰剂或控制意味着月经失血发生在氨甲环酸治疗女性月经过多;这种药物也被用于良好的效果在胎盘出血,产后出血和conisation子宫颈。氨甲环酸显著降低意味着血液损失在血友病患者口腔手术后,有效的漱口水在牙科患者口服抗凝血剂。 Reductions in blood loss were also obtained with the use of the drug in patients undergoing orthotopic liver transplantation or transurethral prostatic surgery, and rates of rebleeding were reduced in patients with traumatic hyphaema. Clinical benefit has also been reported with tranexamic acid in patients with hereditary angioneurotic oedema. Tranexamic acid is well tolerated; nausea and diarrhoea are the most common adverse events. Increased risk of thrombosis with the drug has not been demonstrated in clinical trials. CONCLUSIONS: Tranexamic acid is useful in a wide range of haemorrhagic conditions. The drug reduces postoperative blood losses and transfusion requirements in a number of types of surgery, with potential cost and tolerability advantages over aprotinin, and appears to reduce rates of mortality and urgent surgery in patients with upper gastrointestinal haemorrhage. Tranexamic acid reduces menstrual blood loss and is a possible alternative to surgery in menorrhagia, and has been used successfully to control bleeding in pregnancy.

beplay体育安全吗DrugBank数据引用了这篇文章

药物靶点

药物	目标	类	生物	药理作用	行动
氨甲环酸	Plasminogen	蛋白质	人类	是的	抑制剂	细节