试点研究的vinorelbine (Navelbine)和紫杉醇(紫杉醇)难治性乳腺癌和肺癌患者。

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Chang AY, Garrow GC

试点研究的vinorelbine (Navelbine)和紫杉醇(紫杉醇)难治性乳腺癌和肺癌患者。

4月Semin杂志。1995;22 (2 5 5):66 - 70;讨论70 - 1。

PubMed ID

7740336 (在PubMed

]

文摘

Vinorelbine (Navelbine;伯勒斯威康公司Research Triangle Park,数控;皮埃尔·法布尔药剂,法国巴黎)和紫杉醇(紫杉醇;百时美施贵宝肿瘤学,普林斯顿,纽约)单药治疗在乳腺癌和肺癌具有良好的活动。并发vinorelbine和紫杉醇达到协同细胞毒性对MCF-7和乳腺癌mda - mb - 231细胞体外。因为这些代理绑定到不同的网站微管蛋白,影响微管在相反的方面,一个试点研究vinorelbine和紫杉醇的转移性乳腺癌或肺癌患者是一线化疗耐火材料。入口准则包括可衡量的疾病、Karnofsky性能状态> = 70,足够的骨髓储备,足够的肝和肾的功能,没有中枢神经系统转移。七个患者进入研究(与肺癌1与乳腺癌和6;三个男人和四个女人的年龄39到79年)。前三个患者接受静脉注射vinorelbine 25 mg / m2 5到10分钟天1和8日和紫杉醇静脉注射90 mg / m2 / 3小时后第一天vinorelbine管理。 Premedication prior to paclitaxel consisted of dexamethasone, cimetidine, and diphenhydramine. The subsequent four patients enrolled in the study received the identical dose of vinorelbine, but the paclitaxel dose was increased to 175 mg/m2 in the same sequence. Patients received granulocyte colony-stimulating factor 5 micrograms/kg subcutaneously from days 3 to 17 (except day 8) or until the absolute granulocyte count was 10,000/microL or higher. Preliminary results showed that one of the first three patients developed grade 4 neutropenia and grade 5 infection. In the subsequent four patients, there were two grade 3 and two grade 4 cases of neutropenia; leukopenic fever or infection did not occur. Two patients required red blood cell transfusions. Two patients developed grade 1 and one patient developed grade 2 peripheral neuropathy. Myalgia and fatigue were common but self-limited. The one patient with breast cancer had a partial response; no response was noted in the lung cancer patients.

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药物靶点

药物	目标	类	生物	药理作用	行动
Vinorelbine	微管蛋白β链	蛋白质	人类	是的	拮抗剂 抑制剂	细节