两个截然不同的5 -羟色胺受体:地区差异在哺乳动物大脑受体结合。
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Peroutka SJ,斯奈德SH
两个截然不同的5 -羟色胺受体:地区差异在哺乳动物大脑受体结合。
大脑研究》1981年3月16日,208 (2):339 - 47。
- PubMed ID
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7214150 (在PubMed]
- 文摘
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两个截然不同的5 -羟色胺受体在哺乳动物大脑分别标记为[3 h] 5 -羟色胺(5-HT1)和[3 h] spiperone (5-HT2)。一般受体激动剂显示最高亲和力5-HT1而拮抗剂喜欢5-HT2网站。进行区域研究5 -受体,我们估计与[3 h] spiperone 5-HT2网站,使用5-HT2特定对手cinanserin取代绑定5-HT2但不是多巴胺受体和舒必利取代[3 h] spiperone多巴胺受体而不是5。beplayapp大约15%的大脑皮质[3 h] spiperone绑定似乎包括多巴胺网站和其余涉及5-HT2受体。纹状体中大约80%的[3 h] spiperobeplayappne绑定标签多巴胺受体和其他涉及5-HT2网站。[3 h]米安色林对同样5-HT2和组胺beplayappH1-receptors绑定。[3 h]米安色林与5-HT2网站的互动研究选择性通过取代组织胺H1-receptor绑定H1-antihistamine曲普立啶。[3 h] LSD标签5-HT1和5-HT2受体。其绑定5-HT1网站与5 -流离失所的选择性,而其绑定5-HT2受体与cinanserin流离失所。[3 h] 5标签只有5-HT1受体。 The regional distribution of the two 5-HT receptors is similar in rat, guinea pig and bovine brain. However, the regional patterns of 5-HT1 and 5-HT2 receptors differ considerably in all 3 species. The hippocampus is quite high in 5-HT1 receptors but low in 5-HT2 sites. The cerebellum contains the lowest levels of both 5-HT1 and 5-HT2 receptors. In bovine brain, most areas contain similar numbers of 5-HT1 and 5-HT2 receptors. However, the substantia nigra, the richest 5-HT1 area in bovine brain, possesses 10 times more 5-HT1 than 5-HT2 sites.