修改性行为Long-Evans雄性老鼠的药物作用于5-HT1A受体。
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拉赫曼J, Kaynan基督,G, Valcic M, Maayani年代,梅尔曼
修改性行为Long-Evans雄性老鼠的药物作用于5-HT1A受体。
大脑研究》1999年3月13日,821(2):414 - 25所示。
- PubMed ID
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10064829 (在PubMed]
- 文摘
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调制性行为的雄性老鼠的抗焦虑药丁螺环酮(s - 20499)及其模拟gepirone相比8-OH-DPAT的影响(或DPAT选择性5-HT1A引用受体激动剂),和我- 7378(选择性5-HT1A部分激动剂)。Long-Evans老鼠使用;调制的交配的行为和阴茎的反射进行变更。调制的交配的行为是由三个指标进行评估:频率和插入的长度,和延迟射精。DPAT剂1 - 8毫克/公斤,减少了时间依赖的方式这三个指标的影响达到45分钟和90分钟。量效关系正常化(45分钟DPAT注射后评估)是钟形的ED50大约1毫克/公斤的提升肢体曲线。丁螺环酮的影响(2毫克/公斤)和gepirone(2毫克/公斤)对交配的行为与控制是没有区别的。勃列仅7378,结合其他5-HT1A受体激动剂降低交配的行为,但没有统计学意义。勃起的阴茎反射,包括数量,杯子和翻转,抑制了这些代理:DPAT >丁螺环酮> gepirone(活动2毫克/公斤)。此外,安装至少一倍的潜伏期DPAT(2毫克/公斤)。然而,丁螺环酮和gepirone减少勃起潜伏期。 BMY-7378 inhibited penile reflexes when administered alone and even more in combination with DPAT or buspirone. Two butyrophenone analogs, spiperone (a 5-HT1A and dopamine D2 antagonist) and haloperidol (a D2 antagonist), were also tested for their interaction with DPAT. Both of these drugs (at 0.25 mg/kg, 60 min after administration) reduced all indices of penile reflexes and copulation. Furthermore, in combination with DPAT (2 mg/kg, 45 min), the effects were synergistic such that sexual activity came nearly to a standstill. These opposing effects on putatively brain originated copulatory behavior and spinal mediated penile reflexes indicate that the effects of buspirone and DPAT on sexual behavior in the male rat may be possible at different parts of the central nervous system. If a tentative shared target site by DPAT and buspirone is the 5-HT1A receptor, than the same 5-HT receptor sub-type at different locations (brain, raphe nuclei, spinal cord and autonomic ganglia) may modulate rat sexual behavior in opposing ways.