乌头生物碱的影响songorine突触传递和paired-pulse便利化鼠海马CA1锥体细胞片。
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乌头生物碱的影响songorine突触传递和paired-pulse便利化鼠海马CA1锥体细胞片。
Br J杂志。1998年10月,125 (3):461 - 8。
- PubMed ID
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9806328 (在PubMed]
- 文摘
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1。本研究调查songorine的电生理效应(1 100 microM),一种生物碱发生在乌头属植物,在鼠海马切片。2。microM Songorine(10 - 100)诱发浓度增加顺行的人口高峰的振幅和字段e.p.s.p。增强的斜率是持久而不是逆转了90分钟的冲刷。Songorine未能影响突触前纤维峰值的大小和形状代表谢弗络脉的复合动作电位。这表明突触反应的增强没有传入兴奋性增加的结果。3所示。antidromically诱发人口高峰并不影响songorine浓度高达100 microM建议增强顺行的人口的激增和田野的e.p.s.p.不是由于锥体细胞兴奋性的增加。4突触后人口高峰的输入输出曲线左移暗示相同大小的突触前纤维飙升引起突触后反应更大,表明减少阈值代人口的增加。5。 The songorine-evoked increase in excitability was not affected by the NMDA receptor antagonist, D-AP5. However, the effect of songorine was completely abolished by the selective dopamine D2 receptor antagonist sulpiride (0.1 microM) as well as by haloperidol (10 microM) and was mimicked by application of the dopamine releaser, amantadine (100 mM). In contrast, the selective D1 receptor antagonist, SCH23390, did not block the action of songorine. 6. The results indicate that the plant alkaloid songorine enhances excitatory synaptic transmission which may be due to an agonistic action at D2 receptors.