晶体结构heterodimeric复杂的RAR和RXR配体结合域。
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Bourguet W, V,万岁(拉丁语)维尔茨JM, Chambon P, Gronemeyer H,莫拉D
晶体结构heterodimeric复杂的RAR和RXR配体结合域。
摩尔细胞。2000年2月;5 (2):289 - 98。
- PubMed ID
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10882070 (在PubMed]
- 文摘
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配体结合域之间的异质二聚体的晶体结构(精神的小黑裙)人类的rarα绑定到一个选择性拮抗剂和持续活跃的老鼠RXRalphaF318A变异表明,把笨重的配体的延伸,rarα螺旋H12采用拮抗剂的位置。意外的脂肪酸的配体结合口袋RXRalpha (F318A可能占其明显的“constitutivity。”Specific conformational changes suggest the structural basis of pure and partial antagonism. The RAR-RXR heterodimer interface is similar to that observed in most nuclear receptor (NR) homodimers. A correlative analysis of 3D structures and sequences provides a novel view on dimerization among members of the nuclear receptor superfamily.