Tinzaparin钠:回顾其药理学和临床使用血栓栓塞疾病的预防和治疗。

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SM带来欢乐,邓恩CJ,福斯特R

Tinzaparin钠:回顾其药理学和临床使用血栓栓塞疾病的预防和治疗。

药。2004;64 (13):1479 - 502。

PubMed ID

15212562 (在PubMed

]

文摘

Tinzaparin钠(Tinzaparin;innohep)是一种低分子量肝素(LMWH)形成的酶促降解猪依诺肝素钠(能)。在临床试验中,每日一次皮下(SC) tinzaparin是有效和一般耐受性良好的预防和治疗血栓栓塞疾病。SC tinzaparin anti-Xa 75 IU /公斤/天显示类似thromboprophylactic功效adjusted-dosage在全髋关节置换术患者口服华法林;在接受膝关节置换的患者深静脉血栓形成(DVT)的发病率与tinzaparin显著降低。该药物也有类似的功效在矫形外科equivalent-dosage SC伊诺肝素钠。一般手术的病人,SC tinzaparin anti-Xa 3500 IU /天是同等thromboprophylactic有效性的SC超高频每天5000 IU两次。鼓励取得了初步结果与tinzaparin预防深静脉血栓形成患者的完整运动麻痹。在最初的治疗急性近端深静脉血栓形成和肺栓塞,SC tinzaparin anti-Xa 175 IU /公斤/天至少adjusted-dosage静脉注射(IV)超高频一样有效。的门诊治疗静脉血栓,tinzaparin表明类似的功效dalteparin (dalteparin)和华法林钠。 Tinzaparin was effective in preventing clotting in haemodialysis circuits; the anticoagulant efficacy of tinzaparin in patients undergoing haemodialysis was similar to that of SC dalteparin and similar to or less than (although in this case the tinzaparin dose was too low for sufficient anticoagulant efficacy) that of IV UFH. Advantages of tinzaparin over UFH and warfarin include ease of administration and lack of need for laboratory monitoring. Tinzaparin is more cost effective than UFH in the treatment of established thromboembolic disease, and home-based treatment with tinzaparin may offer greater cost benefits than hospital-based therapy. Tinzaparin is well tolerated, including in elderly patients and those with renal impairment receiving long-term treatment. Incidences of major bleeding complications were low and reports of heparin-induced thrombocytopenia were infrequent in clinical studies. In conclusion, tinzaparin is a valuable LMWH in the prophylaxis and management of thromboembolic disease.

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药物

Tinzaparin